ArticleInternational journal of molecular sciences2023
Repair of Long Peripheral Nerve Defects in Sheep: A Translational Model for Nerve Regeneration.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment.Regenerative medicine · 2024Pooled it
- A Multicenter Matched Cohort Study of Processed Nerve Allograft and Autograft in Mixed and Motor Nerve Reconstruction.Journal of hand surgery global online · 2027Article
- Peripheral nerve repair: innovations and future directions.Journal of translational medicine · 2026Review
- Comparative analysis of Antigliotic Guiding Regenerative Gel (AGRG - LDP-916) for peripheral nerve reconstruction: Evidence from prospective randomized controlled studies.Brain & spine · 2026Review
- Biphasic Electrical Stimulation of Schwann Cells on Conducting Polymer-Coated Carbon Microfibers.International journal of molecular sciences · 2025Article
- Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future.Materials today. Bio · 2025Review
- Biomechanical Evaluation of the Sheep Common Peroneal Nerve After Crush Injury.Animals : an open access journal from MDPI · 2025Article
- Design of AgNPs loaded γ-PGA chitosan conduits with superior antibacterial activity and nerve repair properties.Frontiers in bioengineering and biotechnology · 2025Article
- Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model.Frontiers in cell and developmental biology · 2025Article
- Peripheral nerve regeneration: a challenge far from being overcome.Regenerative medicine · 2024Article
- Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects.Bioactive materials · 2024Article
- Article
- Ultrasound Landmarks in the Approach to the Common Peroneal Nerve in a Sheep Model-Application in Peripheral Nerve Regeneration.Life (Basel, Switzerland) · 2023Article
- Mesenchymal Stem Cells in Nerve Tissue Engineering: Bridging Nerve Gap Injuries in Large Animals.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Despite advances in microsurgery, full functional recovery of severe peripheral nerve injuries is not commonly attained. The sheep appears as a good preclinical model since it presents nerves with similar characteristics to humans. In this study, we induced 5 or 7 cm resection in the peroneal nerve and repaired with an autograft. Functional evaluation was performed monthly. Electromyographic and ultrasound tests were performed at 6.5 and 9 months postoperation (mpo). No significant differences were found between groups with respect to functional tests, although slow improvements were seen from 5 mpo. Electrophysiological tests showed compound muscle action potentials (CMAP) of small amplitude at 6.5 mpo that increased at 9 mpo, although they were significantly lower than the contralateral side. Ultrasound tests showed significantly reduced size of tibialis anterior (TA) muscle at 6.5 mpo and partially recovered size at 9 mpo. Histological evaluation of the grafts showed good axonal regeneration in all except one sheep from autograft 7 cm (AG7) group, while distal to the graft there was a higher number of axons than in control nerves. The results indicate that sheep nerve repair is a useful model for investigating long-gap peripheral nerve injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.