Evidence map›Paper›PMID 36674792›Full record

ArticleInternational journal of molecular sciences2023

A Genome-Wide Functional Screen Identifies Enhancer and Protective Genes for Amyloid Beta-Peptide Toxicity.

Pol Picón-Pagès, Mònica Bosch-Morató, Laia Subirana, Francisca Rubio-Moscardó, Biuse Guivernau, Hugo Fanlo-Ucar, Melisa Ece Zeylan, Simge Senyuz, Víctor Herrera-Fernández, Rubén Vicente and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Pol Picón-PagèsLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Mònica Bosch-MoratóLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Laia SubiranaDepartment of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Francisca Rubio-MoscardóLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Biuse GuivernauLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Hugo Fanlo-UcarLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0001-7420-6501
Melisa Ece ZeylanComputational Sciences and Engineering, Koc University, Istanbul 34450, Turkey.ORCID 0000-0001-8133-8940
Simge SenyuzComputational Sciences and Engineering, Koc University, Istanbul 34450, Turkey.
Víctor Herrera-FernándezLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0001-8895-5765
Rubén VicenteLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0003-0401-4808
José M Fernández-FernándezLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0003-2330-8449
Jordi García-OjalvoLaboratory of Dynamical Systems Biology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0002-3716-7520
Attila GursoyCollege of Engineering, Koc University, Istanbul 34450, Turkey.
Ozlem KeskinCollege of Engineering, Koc University, Istanbul 34450, Turkey.
Baldomero OlivaLaboratory of Structural Bioinformatics (GRIB), Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0003-0702-0250
Francesc PosasDepartment of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Eulàlia de NadalDepartment of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0003-0039-5607
Francisco J MuñozLaboratory of Molecular Physiology, Department of Medicine and Life Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.ORCID 0000-0002-1343-3599
Universitat Pompeu Fabra · ESKoç University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried out a genome-wide screen in

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCalciumCalcium ChannelsCell DeathHumansMammalsMembrane ProteinsPeptide FragmentsAmyloid beta-PeptidesCalciumCalcium ChannelsMembrane ProteinsPeptide FragmentsSURF4 protein, humanAlzheimer’s diseaseamyloid beta-peptidecalciumgenome-wide screeningSOCESURF4

Identifiers

PMID36674792
PMCPMC9865122
OpenAlexW4313826675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.