Evidence map›Paper›PMID 36674783›Full record

ArticleInternational journal of molecular sciences2023

Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on

Shanez Haouari, Christian Robert Andres, Debora Lanznaster, Sylviane Marouillat, Céline Brulard, Audrey Dangoumau, Devina Ung, Charlotte Veyrat-Durebex, Frédéric Laumonnier, Hélène Blasco and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Shanez HaouariUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
Christian Robert AndresUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.ORCID 0000-0002-5062-3156
Debora LanznasterUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.ORCID 0000-0001-5911-3120
Sylviane MarouillatUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
Céline BrulardUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
Audrey DangoumauUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.ORCID 0000-0002-5038-1839
Devina UngUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
Charlotte Veyrat-DurebexUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.ORCID 0000-0003-4512-2303
Frédéric LaumonnierUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.ORCID 0000-0003-2567-0708
Hélène BlascoUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
Philippe CouratierCentre SLA, CHU Limoges, 2 Avenue Martin Luther King, 87000 Limoges, France.
Philippe CorciaUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
Patrick Vourc'hUMR 1253 iBrain, Université de Tours, Inserm, 10 Boulevard Tonnellé, 37032 Tours, France.
French ALS network FILSLAN
Université de Tours · FRCentre Hospitalier Universitaire de Limoges · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ubiquitin pathway, one of the main actors regulating cell signaling processes and cellular protein homeostasis, is directly involved in the pathophysiology of amyotrophic lateral sclerosis (ALS). We first analyzed, by a next-generation sequencing (NGS) strategy, a series of genes of the ubiquitin pathway in two cohorts of familial and sporadic ALS patients comprising 176 ALS patients. We identified several pathogenic variants in different genes of this ubiquitin pathway already described in ALS, such as

Indexed as

Amyotrophic Lateral SclerosisAdaptor Proteins, Signal TransducingAutophagy-Related ProteinsHumansNerve Tissue ProteinsNeuronsSignal TransductionUbiquitinUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingAutophagy-Related ProteinsHECW1 protein, humanNerve Tissue ProteinsUbiquitinUbiquitin-Protein LigasesUBQLN2 protein, humanALSamyotrophic lateral sclerosisgeneticHECW1ubiquitin

Identifiers

PMID36674783
PMCPMC9867363
OpenAlexW4313824505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.