Evidence map›Paper›PMID 36674774›Full record

ArticleInternational journal of molecular sciences2023

Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases.

Maybelle Kho Go, Tingting Zhu, Kevin Jie Han Lim, Yossa Dwi Hartono, Bo Xue, Hao Fan, Wen Shan Yew

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. EngineeringBiotechnology reports (Amsterdam, Netherlands) · 2025
    Article
  2. Article
  3. First Report of Hemp Fusarium Wilt Caused byPlants (Basel, Switzerland) · 2023
    Article
  4. Molecular Advances on Cannabinoid and Endocannabinoid Research.International journal of molecular sciences · 2023
    Article
  5. Biosynthesis of Nature-Inspired Unnatural Cannabinoids.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maybelle Kho GoSynthetic Biology for Clinical and Technological Innovation, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.
Tingting ZhuSynthetic Biology for Clinical and Technological Innovation, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.
Kevin Jie Han LimSynthetic Biology for Clinical and Technological Innovation, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.
Yossa Dwi HartonoSynthetic Biology for Clinical and Technological Innovation, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.ORCID 0000-0002-7829-9247
Bo XueSynthetic Biology for Clinical and Technological Innovation, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.ORCID 0000-0002-5172-2519
Hao FanSynthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.ORCID 0000-0003-0199-9752
Wen Shan YewSynthetic Biology for Clinical and Technological Innovation, National University of Singapore, 14 Medical Drive, Singapore 117599, Singapore.ORCID 0000-0002-3021-0469
National University of Singapore · SGAgency for Science, Technology and Research · SG

Funding

Agency for Science, Technology and Research I2001E0068National Research Foundation SBP-P3
6 · The paper itself

Abstract

We report enzymes from the berberine bridge enzyme (BBE) superfamily that catalyze the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA) to form cannabielsoin (CBE). The enzymes are from a variety of organisms and are previously uncharacterized. Out of 232 homologues chosen from the enzyme superfamily, four orthologues were shown to accept CBGA as a substrate and catalyze the biosynthesis of CBE. The four enzymes discovered in this study were recombinantly expressed and purified in

Indexed as

CannabinoidsCannabisCannabidiolCatalysisNitric Oxide SynthaseOxidation-ReductionCannabidiolcannabielsoinCannabinoidsNitric Oxide Synthaseberberine bridge enzymecannabielsoincannabigerolic acidcannabinoid biosynthesiscannabinoid synthasePichia pastoris

Identifiers

PMID36674774
PMCPMC9862763
OpenAlexW4313824281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.