Evidence map›Paper›PMID 36674760›Full record

ArticleInternational journal of molecular sciences2023

Both LTA and LTB Subunits Are Equally Important to Heat-Labile Enterotoxin (LT)-Enhanced Bacterial Adherence.

Qiangde Duan, Shengmei Pang, Lili Feng, Baoliang Li, Linfen Lv, Yuxuan Liang, Guoqiang Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qiangde DuanDepartment of Veterinary Microbiology, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-6934-9142
Shengmei PangDepartment of Veterinary Microbiology, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Lili FengInstitute of Agricultural Economics and Information, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Baoliang LiDepartment of Veterinary Microbiology, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Linfen LvDepartment of Veterinary Microbiology, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yuxuan LiangDepartment of Veterinary Microbiology, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Guoqiang ZhuDepartment of Veterinary Microbiology, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yangzhou University · CNHenan Academy of Agricultural Sciences · CN

Funding

Chinese National Science Foundation 32273002,31800121
6 · The paper itself

Abstract

There is increasing evidence indicating that the production of heat-labile enterotoxin (LT) enhances bacterial adherence within in vitro and in vivo models. However, which subunit plays the main role, and the precise regulatory mechanisms remain unclear. To further elucidate the contribution of the A subunit of LT (LTA) and the B subunit of LT (LTB) in LT-enhanced bacterial adherence, we generated several LT mutants where their ADP-ribosylation activity or GM1 binding ability was impaired and evaluated their abilities to enhance the two LT-deficient

Indexed as

Bacterial ToxinsEscherichia coli ProteinsEnterotoxinsEscherichia coliG(M1) GangliosideHot TemperatureBacterial ToxinsEnterotoxinsEscherichia coli ProteinsG(M1) Gangliosidebacterial adherenceenterotoxigenic Escherichia coliheat-labile enterotoxinLTA subunitLTB subunit

Identifiers

PMID36674760
PMCPMC9863850
OpenAlexW4313824385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.