Predicting Modifiers of Genotype-Phenotype Correlations in Craniofacial Development.

Ranjeet D Kar, Johann K Eberhart

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.5field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ranjeet D KarDepartment of Molecular Biosciences, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.

Johann K EberhartDepartment of Molecular Biosciences, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.

The University of Texas at Austin · US

Funding

Mechanisms underlying the multifaceted basis of craniofacial dysmorphogenesisR35DE029086 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI JOHANN K EBERHART · 2019 to 2026

$7.6M

NIDCR NIH HHS R35 DE029086NIH HHS R35DE029086

6 · The paper itself

Abstract

Most human birth defects are phenotypically variable even when they share a common genetic basis. Our understanding of the mechanisms of this variation is limited, but they are thought to be due to complex gene-environment interactions. Loss of the transcription factor Gata3 associates with the highly variable human birth defects HDR syndrome and microsomia, and can lead to disruption of the neural crest-derived facial skeleton. We have demonstrated that zebrafish

Indexed as

NephrosisZebrafishAnimalsGenetic Association StudiesHumansNeural CrestPhenotypeZebrafish ProteinsZebrafish Proteinscraniofacial developmentGata3neural crestphenotypic variationtranscriptomicszebrafish

Identifiers

PMID36674738

DOI10.3390/ijms24021222

PMCPMC9864425

OpenAlexW4313891018

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.