Evidence map›Paper›PMID 36674688›Full record

ArticleInternational journal of molecular sciences2023

The Predictive Role of Extracellular NAPRT for the Detection of Advanced Fibrosis in Biopsy-Proven Non-Alcoholic Fatty Liver Disease.

Angelo Armandi, Giorgia Colombo, Chiara Rosso, Gian Paolo Caviglia, Antonella Olivero, Maria Lorena Abate, Marta Guariglia, Nuria Perez Diaz Del Campo, Gabriele Castelnuovo, Davide Giuseppe Ribaldone and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Angelo ArmandiDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-7245-4445
Giorgia ColomboDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.
Chiara RossoDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-6518-7089
Gian Paolo CavigliaDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-0529-9481
Antonella OliveroDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-0327-3875
Maria Lorena AbateDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-7611-6099
Marta GuarigliaDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
Nuria Perez Diaz Del CampoDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0003-0479-8825
Gabriele CastelnuovoDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.
Davide Giuseppe RibaldoneDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-9421-3087
Giorgio Maria SaraccoDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0001-5310-4143
Armando A GenazzaniDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.
Elisabetta BugianesiDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-0502-4381
University of Turin · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITJohannes Gutenberg University Mainz · DE

Funding

EPoS (Elucidating Pathways of Steatohepatitis) consortium funded by the Horizon 2020 Framework Program of the European Union 634413Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Università e della Ricerca - MIUR) under the programme "Dipartimenti di Eccellenza 2018 - 2022" D15D18000410001Italian Ministry of Health (Ricerca Finalizzata, Ministero della Salute) RF-2016-02364358
6 · The paper itself

Abstract

Intrahepatic oxidative stress is a key driver of inflammation and fibrogenesis in non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the role of extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) and extracellular nicotinic acid phosphoribosyltransferase (eNAPRT) for the detection of advanced fibrosis. eNAMPT and eNAPRT were tested in 180 consecutive biopsy-proven NAFLD patients and compared with liver stiffness (LS) and the FIB-4 score. eNAMPT was similarly distributed across fibrosis stages, whereas eNAPRT was increased in patients with advanced fibrosis (

Indexed as

Diabetes Mellitus, Type 2Non-alcoholic Fatty Liver DiseaseAlanine TransaminaseBiopsyFibrosisHumansLiverLiver CirrhosisMaleAlanine Transaminaseliver fibrosisNAMPTNAPRTnon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisnon-invasive testsoxidative stressvisfatin

Identifiers

PMID36674688
PMCPMC9861383
OpenAlexW4313816280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.