Evidence map›Paper›PMID 36674637›Full record

ArticleInternational journal of molecular sciences2023

Deciphering the Effect of Different Genetic Variants on Hippocampal Subfield Volumes in the General Population.

Kevin Kirchner, Linda Garvert, Katharina Wittfeld, Sabine Ameling, Robin Bülow, Henriette Meyer Zu Schwabedissen, Matthias Nauck, Henry Völzke, Hans J Grabe, Sandra Van der Auwera

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Kevin KirchnerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.
Linda GarvertDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0001-9067-8170
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.
Sabine AmelingInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-3095-8362
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-1884-5784
Henriette Meyer Zu SchwabedissenDepartment Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0003-0458-4579
Matthias NauckGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17475 Greifswald, Germany.
Henry VölzkeGerman Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 17475 Greifswald, Germany.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.
Sandra Van der AuweraDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-1757-7768
Universitätsmedizin Greifswald · DEUniversity of Basel · CH

Funding

Deutsche Forschungsgemeinschaft 403694598, GR 1912/13-1Federal Ministry of Education and Research 01KU2004
6 · The paper itself

Abstract

The aim of this study was to disentangle the effects of various genetic factors on hippocampal subfield volumes using three different approaches: a biologically driven candidate gene approach, a hypothesis-free GWAS approach, and a polygenic approach, where AD risk alleles are combined with a polygenic risk score (PRS). The impact of these genetic factors was investigated in a large dementia-free general population cohort from the Study of Health in Pomerania (SHIP,

Indexed as

Alzheimer DiseaseMultifactorial InheritanceHippocampusHumansMagnetic Resonance ImagingMicrotubule-Associated ProteinsProtein Serine-Threonine KinasesMAST4 protein, humanMicrotubule-Associated ProteinsProtein Serine-Threonine Kinases5-HTTLPRAPOEBDNFcandidate genesdepressiongeneral populationhippocampal subfieldspolygenic scoretrisynaptic circuitverbal memory

Identifiers

PMID36674637
PMCPMC9861136
OpenAlexW4313891469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.