Evidence map›Paper›PMID 36674620›Full record

ArticleInternational journal of molecular sciences2023

Synthesis, Characterization and Photoactivation Studies on the Novel Pt(IV)-Based [Pt(OCOCH

Giovanni Canil, Juan Gurruchaga-Pereda, Simona Braccini, Lorella Marchetti, Tiziana Funaioli, Fabio Marchetti, Alessandro Pratesi, Luca Salassa, Chiara Gabbiani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Metal-Based Complexes in Cancer.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giovanni CanilCentro di Riferimento Oncologico di Aviano, IRCCS, Via Franco Gallini, 2, 33081 Aviano, Italy.
Juan Gurruchaga-PeredaDonostia International Physics Center, Paseo Manuel de Lardizabal 4, 20018 Donostia, Spain.
Simona BracciniDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0001-8188-9726
Lorella MarchettiDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.
Tiziana FunaioliDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.
Fabio MarchettiDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.
Alessandro PratesiDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0002-9553-9943
Luca SalassaDonostia International Physics Center, Paseo Manuel de Lardizabal 4, 20018 Donostia, Spain.ORCID 0000-0002-2112-9095
Chiara GabbianiDepartment of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy.ORCID 0000-0002-8468-4838

Funding

Severo Ochoa Centres of Excellence Program CEX2018-000867-SSpanish State Research Agency CTQ2016-80844-RUniversity of Pisa PRA_2022-2023_12
6 · The paper itself

Abstract

Photoactivatable Pt(IV) prodrugs represent nowadays an intriguing class of potential metal-based drugs, endowed with more chemical inertness in their oxidized form and better selectivity for the target with respect to the clinically established Pt(II) compounds. In fact, they have the possibility to be reduced by light irradiation directly at the site of interest. For this reason, we synthesized a new Pt(IV) complex, [Pt(OCOCH

Indexed as

Antineoplastic AgentsProdrugsHumansLightMagnetic Resonance SpectroscopyOrganoplatinum CompoundsAntineoplastic AgentsOrganoplatinum CompoundsProdrugsanticancer compoundsflavin-catalyzed light-activationmetal-based drugsphotoactivationPt(IV) compounds

Identifiers

PMID36674620
PMCPMC9864011

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.