Evidence map›Paper›PMID 36674612›Full record

ArticleInternational journal of molecular sciences2023

Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the

Jakub Czarny, Marta Andrzejewska, Olga Zając-Spychała, Elżbieta Latos-Grażyńska, Agata Pastorczak, Kamila Wypyszczak, Aleksandra Szczawińska-Popłonyk, Izabela Niewiadomska-Wojnałowicz, Agnieszka Wziątek, Patrycja Marciniak-Stępak and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jakub CzarnyFaculty of Medicine, Poznan University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0003-4996-9157
Marta AndrzejewskaFaculty of Medicine, Poznan University of Medical Sciences, 61-701 Poznań, Poland.
Olga Zając-SpychałaDepartment of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.
Elżbieta Latos-GrażyńskaDepartment of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wrocław Medical University, 50-556 Wrocław, Poland.
Agata PastorczakDepartment of Pediatrics, Oncology and Hematology, Medical University of Łódź, 91-738 Łódź, Poland.ORCID 0000-0003-3089-6947
Kamila WypyszczakDepartment of Pediatrics, Oncology and Hematology, Medical University of Łódź, 91-738 Łódź, Poland.
Aleksandra Szczawińska-PopłonykDepartment of Pediatric Pneumonology, Allergy and Clinical Immunology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.
Izabela Niewiadomska-WojnałowiczDepartment of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.
Agnieszka WziątekDepartment of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.
Patrycja Marciniak-StępakDepartment of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.
Michał DopierałaDepartment of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.
Jadwiga MałdykDepartment of Pathology, Medical University of Warsaw, 02-106 Warsaw, Poland.
Katarzyna Jończyk-PotocznaDepartment of Pediatric Radiology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.ORCID 0000-0002-9412-8931
Katarzyna DerwichDepartment of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, 60-355 Poznań, Poland.ORCID 0000-0001-7239-4035
Poznan University of Medical Sciences · PLMedical University of Lodz · PLMedical University of Warsaw · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ataxia-telangiectasia (AT) is a multisystemic neurodegenerative inborn error of immunity (IEI) characterized by DNA repair defect, chromosomal instability, and hypersensitivity to ionizing radiation. Impaired DNA double-strand break repair determines a high risk of developing hematological malignancies, especially lymphoproliferative diseases. Poor response to treatment, excessive chemotherapy toxicities, and the need for avoiding exposure to ionizing radiation make the successful clinical management of patients with AT challenging for oncologists. We describe the favorable outcome of the LBCL with

Indexed as

Ataxia TelangiectasiaLymphoma, Large B-Cell, DiffuseAntineoplastic Combined Chemotherapy ProtocolsAtaxia Telangiectasia Mutated ProteinsChildCyclophosphamideDoxorubicinFemaleHumansMethotrexateMutationPositron Emission Tomography Computed TomographyPrednisoneRituximabVincristineAtaxia Telangiectasia Mutated ProteinsATM protein, humanCyclophosphamideDoxorubicinMethotrexatePrednisoneRituximabVincristineataxia-telangiectasiaDNA repairLBCLrituximab

Identifiers

PMID36674612
PMCPMC9866559
OpenAlexW4313648637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.