Evidence map›Paper›PMID 36674577›Full record

ArticleInternational journal of molecular sciences2023

SNAI2 Attenuated the Stem-like Phenotype by Reducing the Expansion of EPCAM

Xian Liu, Ni Zhang, Qian Chen, Qian Feng, Yanru Zhang, Zhiqiang Wang, Xiong Yue, Hongbao Li, Nan Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. A Transcriptomic Analysis of Laryngeal Dysplasia.International journal of molecular sciences · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xian LiuDepartment of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Ni ZhangDepartment of Basic Medicine, Xi'an Medical University, Xin-Wang Street #1, Xi'an 710021, China.
Qian ChenDepartment of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Qian FengDepartment of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Yanru ZhangDepartment of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Zhiqiang WangDepartment of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an 710061, China.
Xiong YueGansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, China.
Hongbao LiDepartment of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an 710061, China.ORCID 0000-0002-1600-9590
Nan CuiDepartment of Reproductive Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0000-0002-4821-6762
Ministry of Education of the People's Republic of China · CNGansu Provincial Maternal and Child Health Hospital · CNXi'an Jiaotong University · CNXi'an Medical University · CN

Funding

Gansu Provincial Science and Technology Department Grant 20JR5RA138the National Natural Science Foundation of China 81903042the National Natural Science Foundation of China 82170443
6 · The paper itself

Abstract

SNAI2 (Snai2) is a zinc-finger transcriptional repressor that belongs to the Snail family. The accumulated evidence suggests that SNAI2 exhibits biphasic effects on regulating a stem-like phenotype in various types of cells, both normal and malignant. In this study, by exogenously expressing SNAI2 in SiHa cells, SNAI2 exhibited the capacity to inhibit a stem-like phenotype in cervical cancer cells. The SNAI2-overexpressing cells inhibited cell growth, tumorsphere formation, tumor growth, enhanced sensitivity to cisplatin, reduced stem cell-related factors' expression, and lowered tumor initiating frequency. In addition, the EPCAM

Indexed as

beta CateninUterine Cervical NeoplasmsCell Line, TumorEpithelial Cell Adhesion MoleculeFemaleHeLa CellsHumansPhenotypeSnail Family Transcription Factorsbeta CateninEPCAM protein, humanEpithelial Cell Adhesion MoleculeSNAI2 protein, humanSnail Family Transcription Factorscervical cancerEPCAMSNAI2stem-like phenotypeβ-catenin

Identifiers

PMID36674577
PMCPMC9864029
OpenAlexW4313647515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.