Evidence map›Paper›PMID 36674550›Full record

ReviewInternational journal of molecular sciences2023

Extracellular Vesicles and Viruses: Two Intertwined Entities.

Coline Moulin, Mathieu J F Crupi, Carolina S Ilkow, John C Bell, Stephen Boulton

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. ERVK activity in CD8Journal of neuroinflammation · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Coline MoulinOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-9692-0906
Mathieu J F CrupiOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-4452-2383
Carolina S IlkowOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
John C BellOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.
Stephen BoultonOttawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-2521-2240

Funding

CIHR 448323
6 · The paper itself

Abstract

Viruses share many attributes in common with extracellular vesicles (EVs). The cellular machinery that is used for EV production, packaging of substrates and secretion is also commonly manipulated by viruses for replication, assembly and egress. Viruses can increase EV production or manipulate EVs to spread their own genetic material or proteins, while EVs can play a key role in regulating viral infections by transporting immunomodulatory molecules and viral antigens to initiate antiviral immune responses. Ultimately, the interactions between EVs and viruses are highly interconnected, which has led to interesting discoveries in their associated roles in the progression of different diseases, as well as the new promise of combinational therapeutics. In this review, we summarize the relationships between viruses and EVs and discuss major developments from the past five years in the engineering of virus-EV therapies.

Indexed as

Extracellular VesiclesVirus DiseasesVirusesAntiviral AgentsHumansAntiviral Agentscancerextracellular vesicles (EVs)gene therapyvirotherapyvirus-host interactions

Identifiers

PMID36674550
PMCPMC9861478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.