Evidence map›Paper›PMID 36674531›Full record

ArticleInternational journal of molecular sciences2023

Determination of the Predictive Roles and Potentially Pathogenic Antigen Epitopes of α-Enolase Related to the Development of Miscarriage in Females with Autoimmune Thyroiditis.

Jiahui Guo, Yihan Lu, Xiaoqing He, Jiashu Li, Chenling Fan, Hongmei Zhang, Weiping Teng, Zhongyan Shan, Jing Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jiahui GuoDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Yihan LuDepartment of International Clinic, The Second Hospital of Dalian Medical University, Dalian 116000, China.
Xiaoqing HeDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Jiashu LiDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Chenling FanDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Hongmei ZhangDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Weiping TengDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Zhongyan ShanDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
Jing LiDepartment of Endocrinology and Metabolism, Institute of Endocrinology, The NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001, China.
First Hospital of China Medical University · CNDalian Medical University · CN

Funding

Distinguished Professor at Educational Department of Liaoning Province (2014)187National Nature Science Foundation of China 81570709National Nature Science Foundation of China 81771741National Science and Technology Support Program 2014BA106B02
6 · The paper itself

Abstract

Autoimmune thyroiditis (AIT) is a common endocrine disease which causes a significantly increased risk of miscarriage. Our recent study has shown that the increased ENO1 autoantibody (ENO1Ab) expression in an experimental AIT mouse model was induced by thyroglobulin (Tg) immunization only. In this study, we explored the potential roles of ENO1Ab in miscarriage occurrence among AIT women, and the specific epitopes of ENO1 targeted by ENO1Ab. A total of 432 euthyroid pregnant participants were selected from the project of Subclinical Hypothyroid during Early Pregnancy, including 48 women with AIT and miscarriage, 96 with miscarriage but no AIT, 96 with AIT but no miscarriage, and 192 without either AIT or miscarriage. The enzyme-linked immunosorbent assay was used to determine the serum levels of total IgG against ENO1 and 18 predicted antigen epitopes of ENO1. The results showed that women with AIT and miscarriage had the highest serum levels of ENO1Ab compared to the other groups. Logistic regression analysis showed that the serum ENO1Ab was an independent risk factor for miscarriage, especially among AIT females. The serum level of total IgG against the predicted epitope peptide 6 (i.e., P6 and aa168-183) of ENO1 was significantly increased in women with AIT and miscarriage when compared with those of both the AIT non-miscarriage group and non-AIT miscarriage group. This pilot study suggests that serum ENO1Ab may have a fair predictive value for AIT-related miscarriage, and the autoantibody specific to P6 epitope may especially be more specifically related to this disorder.

Indexed as

Abortion, SpontaneousThyroiditis, AutoimmuneAnimalsAutoantibodiesDNA-Binding ProteinsEpitopesFemaleHashimoto DiseaseImmunoglobulin GMicePhosphopyruvate HydratasePilot ProjectsPregnancyTumor Suppressor ProteinsAutoantibodiesDNA-Binding ProteinsENO1 protein, humanEpitopesImmunoglobulin GPhosphopyruvate HydrataseTumor Suppressor Proteinsantigen epitopeautoimmune thyroiditisENO1Abmiscarriagepeptide 6

Identifiers

PMID36674531
PMCPMC9862122
OpenAlexW4313574431

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.