Evidence map›Paper›PMID 36674516›Full record

ArticleInternational journal of molecular sciences2023

Obesity Modifies the Proteomic Profile of the Periodontal Ligament.

Andressa V B Nogueira, Maria Eduarda S Lopes, Camila C Marcantonio, Cristiane R Salmon, Luciana S Mofatto, James Deschner, Francisco H Nociti-Junior, Joni A Cirelli

Open access · goldAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Andressa V B NogueiraDepartment of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0002-2756-5947
Maria Eduarda S LopesDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, São Paulo State University-UNESP, Araraquara 14801-903, São Paulo, Brazil.
Camila C MarcantonioDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, São Paulo State University-UNESP, Araraquara 14801-903, São Paulo, Brazil.ORCID 0000-0002-0610-7074
Cristiane R SalmonDepartment of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, São Paulo, Brazil.ORCID 0000-0003-3304-5064
Luciana S MofattoDepartment of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, São Paulo, Brazil.ORCID 0000-0002-2087-7251
James DeschnerDepartment of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Francisco H Nociti-JuniorDepartment of Prosthodontics and Periodontics, Division of Periodontics, Piracicaba Dental School, University of Campinas-UNICAMP, Piracicaba 13414-903, São Paulo, Brazil.ORCID 0000-0001-6809-8866
Joni A CirelliDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, São Paulo State University-UNESP, Araraquara 14801-903, São Paulo, Brazil.ORCID 0000-0002-7082-9290
Centro Universitário de Araraquara · BRUniversidade Estadual de Campinas (UNICAMP) · BRJohannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft DE 1593/5-1São Paulo Research Foundation 2014/20715-7 and 2017/07137-2
6 · The paper itself

Abstract

This study aimed to assess the obesity effects on the proteomic profile of the periodontal ligament of rats submitted to obesity induction by a high-fat diet. Eight Holtzman rats were divided into control (n = 3) and obese (n = 5) groups. The maxillae were histologically processed for laser capture microdissection of the periodontal ligament of the first maxillary molars. Peptide mixtures were analyzed by LC-MS/MS. A total of 1379 proteins were identified in all groups. Among them, 335 (24.30%) were exclusively detected in the obese group, while 129 (9.35%) proteins were uniquely found in the control group. Out of the 110 (7.98%) differentially abundant proteins, 10 were more abundant and 100 had decreased abundance in the obese group. A gene ontology analysis showed some proteins related to obesity in the “extracellular exosome” term among differentially identified proteins in the gene ontology cellular component terms Prelp, Sec13, and Sod2. These three proteins were upregulated in the obese group (p < 0.05), as shown by proteomic and immunohistochemistry analyses. In summary, our study presents novel evidence that the proteomic profile of the periodontal ligament is altered in experimental obesity induction, providing a list of differentially abundant proteins associated with obesity, which indicates that the periodontal ligament is responsive to obesity.

Indexed as

Periodontal LigamentProteomicsAnimalsChromatography, LiquidExtracellular Matrix ProteinsObesityProteinsRatsTandem Mass SpectrometryExtracellular Matrix ProteinsPrelp protein, ratProteinsobesityperiodontal ligamentprolarginprotein Sec13 homologproteomicssuperoxide dismutase

Identifiers

PMID36674516
PMCPMC9861657
OpenAlexW4313576781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.