Evidence map›Paper›PMID 36674444›Full record

ArticleInternational journal of molecular sciences2023

DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex.

Huifei Sophia Zheng, Yuan Kang, Qiongxia Lyu, Kristina Junghans, Courtney Cleary, Olivia Reid, Greer Cauthen, Karly Laprocina, Chen-Che Jeff Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Huifei Sophia ZhengDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Yuan KangDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Qiongxia LyuDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Kristina JunghansDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Courtney ClearyDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Olivia ReidDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Greer CauthenDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Karly LaprocinaDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
Chen-Che Jeff HuangDepartment of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-0376-4682
Auburn University · US

Funding

Thyroid hormone receptors and adrenocortical remodeling.R00HD082686 · NICHD · AUBURN UNIVERSITY AT AUBURN · PI HUANG, CHEN-CHE JEFF · 2018 to 2020
$747k
Deciphering the protective effect of the transient marker gene, Dhcr24, in the adrenal gland inner cortex.R03AG065518 · NIA · AUBURN UNIVERSITY AT AUBURN · PI HUANG, CHEN-CHE JEFF · 2022 to 2023
$149k
NIA NIH HHS R03 AG065518NICHD NIH HHS R00 HD082686NIH HHS R00HD082686, R03AG065518
6 · The paper itself

Abstract

Steroid hormones are synthesized through enzymatic reactions using cholesterol as the substrate. In steroidogenic cells, the required cholesterol for steroidogenesis can be obtained from blood circulation or synthesized de novo from acetate. One of the key enzymes that control cholesterol synthesis is 24-dehydrocholesterol reductase (encoded by

Indexed as

CorticosteroneOxidoreductases Acting on CH-CH Group DonorsAdrenal GlandsAnimalsCholesterolFemaleHumansMiceNerve Tissue ProteinsRatsZona FasciculataCholesterolCorticosteroneDHCR24 protein, humanDhcr24 protein, mouseDHCR24 protein, ratNerve Tissue ProteinsOxidoreductases Acting on CH-CH Group Donorsadrenal gland inner cortexDHCR24seladin-1X-zone

Identifiers

PMID36674444
PMCPMC9867314
OpenAlexW4313584079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.