Evidence map›Paper›PMID 36674434›Full record

ArticleInternational journal of molecular sciences2023

The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ

Dai Shi, Jaime K Y Wong, Kaichuan Zhu, Peter G Noakes, Gerhard Rammes

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Molecular Mechanism of Alzheimer's Disease.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Dai ShiDepartment of Anesthesiology and Intensive Care, Klinikum Rechts der Isar, Ismaningerstraße 22, 81675 Munich, Germany.
Jaime K Y WongSchool of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia.
Kaichuan ZhuGerman Center for Neurodegenerative Diseases, Feodor-Lynen-Straße 23, 81377 Munich, Germany.
Peter G NoakesSchool of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-9821-8478
Gerhard RammesDepartment of Anesthesiology and Intensive Care, Klinikum Rechts der Isar, Ismaningerstraße 22, 81675 Munich, Germany.
The University of Queensland · AUTUM Klinikum · DEGerman Center for Neurodegenerative Diseases · DE

Funding

National Health and Medical Council Australia Ideas Grant NHMRC 1188169
6 · The paper itself

Abstract

It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer's disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of synapses is regarded as one key cause of dementia in AD. Multiple EGF-like domains 10 (MEGF10) is one of the phagocytic receptors which assists the elimination of synapses by astrocytes. Here, we investigated how β-amyloid peptide 1-42 (Aβ

Indexed as

Alzheimer DiseaseAnesthetics, InhalationIsofluraneAmyloid beta-PeptidesAnimalsAstrocytesBrainHippocampusMembrane ProteinsMicePeptide FragmentsSynapsesXenonAmyloid beta-Peptidesamyloid beta-protein (1-42)Anesthetics, InhalationIsofluraneMegf10 protein, mouseMembrane ProteinsPeptide FragmentsXenonAlzheimer’s diseaseastrocytesdendritic spine densityMEGF10phagocytosissynapse elimination

Identifiers

PMID36674434
PMCPMC9861496
OpenAlexW4313588243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.