ArticleInternational journal of environmental research and public health2023
Adverse Childhood Experiences and Chronic Diseases: Identifying a Cut-Point for ACE Scores.
Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Understanding adverse childhood experiences within the first decade of the ABCD study: A systematic review.Developmental cognitive neuroscience · 2026Pooled it
- Clavulanic acid is associated with moderation of cigarette use in patients with cocaine use disorder: A post-hoc analysis.Drug and alcohol dependence · 2026Trial
- Social emotional learning and autonomic regulation enhance social connectedness in female adolescents with extensive exposure to adverse childhood experiences.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Caregiver Adverse Childhood Experiences, Resilience, and Mental Health in a Predominantly Hispanic Pediatric Clinic Setting.Journal of child & adolescent trauma · 2026Article
- Selected Teen-Reported Adverse Childhood Experiences (ACEs) and Mental Health Care Use.Academic pediatrics · 2026Article
- Childhood adversity and self-rated health disparities by citizenship in middle-aged-and-older Latino adults in California.Preventive medicine reports · 2026Article
- The Prevalence of Stressful Life Events among a Racially Diverse National Sample of Adolescents.Research square · 2026Article
- Childhood and Prenatal Stressors Shape Breastfeeding Behavior in Individuals with Opioid Use Disorder: A Prospective Investigation of Stress Effects.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2025Article
- Examining bidirectional associations between cannabis use and internalizing symptoms among high-risk emerging adults: A prospective cohort study.Psychological medicine · 2025Article
- Adverse Childhood Experiences, Psychological Distress, and Resilience in Health Professions Students.Academic medicine : journal of the Association of American Medical Colleges · 2025Article
- Trauma-informed care implementation among nurses in Saudi Arabia: a cross-sectional descriptive study.BMC nursing · 2025Article
- Skin-deep resilience in the Black women's experiences living with lupus study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Adverse childhood experiences are associated with job burnout in nursing interns: the mediation role of sleep duration.BMC nursing · 2025Article
- Explaining the Self-Care Behaviors in Type 2 Diabetic Patients Based on Adverse Childhood Experiences, Subjective Socioeconomic Status, and Mindfulness in Isfahan, Iran.Health science reports · 2025Article
- Exploring social impairment in those with opioid use disorder: linking impulsivity, childhood trauma, and the prefrontal cortex.BMC psychiatry · 2025Article
- Beyond diagnosis: symptom patterns across complex PTSD and borderline personality disorder.Frontiers in psychiatry · 2025Article
- Adverse childhood experiences affect health outcomes for adults in North Dakota: 2019-2022 BRFSS population profile.Frontiers in public health · 2025Article
- Adverse childhood experiences and risky behaviors in Oman: A cross-sectional study.Preventive medicine reports · 2024Article
- Exploring Social Impairment in Those with Opioid Use Disorder: Linking Impulsivity, Childhood Trauma, and the Prefrontal Cortex.Research square · 2024Article
- Serial Dual Mediating Effects of Parenting Stress on Life Satisfaction among Parents of School-Aged Children with Chronic Conditions.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse Childhood Experiences (ACEs) contribute to many negative physiological, psychological, and behavioral health consequences. However, a cut-point for adverse childhood experience (ACE) scores, as it pertains to health outcomes, has not been clearly identified. This ambiguity has led to the use of different cut-points to define high scores. The aim of this study is to clarify a cut-point at which ACEs are significantly associated with negative chronic health outcomes. To accomplish this aim, a secondary analysis using data from a cross-sectional study was conducted. The Adverse Childhood Experiences-International Questionnaire (ACE-IQ) was used for data collection. Descriptive statistics, nonparametric regression, and logistic regression analyses were performed on a sample of 10,047 adults. Data from demographic and self-report health measures were included. The results showed that a cut-point of four or more ACEs was significantly associated with increased rates of chronic disease. Participants with at least one chronic disease were almost 3 times more likely (OR = 2.8) to be in the high ACE group. A standardized cut-point for ACE scores will assist in future research examining the impact of high ACEs across cultures to study the effect of childhood experiences on health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.