ArticleInternational journal of environmental research and public health2023
Syphilis, the Great Imitator-Clinical and Dermoscopic Features of a Rare Presentation of Secondary Syphilis.
Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Clinical and Dermoscopic Correlation in Secondary Syphilis: A Report of Three Cases.Indian dermatology online journal · 2026Article
- Letter to the editor in response to "Rare presentation of lues maligna and nodular syphilis in an immunocompetent patient".JAAD case reports · 2026Article
- The use of non-mydriatic ocular fundus imaging in the emergency department for detection of ocular syphilis presenting as presumed "papilledema": a case series.Frontiers in neurology · 2026Article
- Radiomics analysis for the early diagnosis of common sexually transmitted infections and skin lesions.PLOS digital health · 2025Article
- A Rare Case of Lichen Planus Mimicking Secondary Syphilis: The Great Imitator Unveiled.Cureus · 2025Article
- The Rise of Syphilis Infections and Reinfections over a Decade (2009-2019) in the Bolognese Area: A Retrospective Analysis.Microorganisms · 2025Article
- Article
- Oral Secondary Syphilis in an HIV-Positive Transgender Patient: A Case Report and Review of the Literature.Dentistry journal · 2023Article
- Neurosyphilis With Concomitant Respiratory Failure: A Case Study and Treatment Considerations.Cureus · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis is characterized by a wide range of variable clinical symptoms; therefore, it is often referred to as "The Great Imitator". Here, we report the case of a 69-year-old hepatitis-C-positive MSM patient, who was admitted to our clinic due to a solitary firm painless erythematous maculopapular lesion with a central crater-like crust on the upper right thigh that occurred two months prior. The dermoscopy showed an erythematous, copper-colored, oval lesion with diffuse monomorphic dotted and glomerular vessels, central crust, and circular scaling (Biett's sign). The histological findings ruled out neoplasia and described a plasma cell infiltrate and endothelial swelling. Finally, the combination of the dermoscopic image, histological findings and the additionally acquired knowledge about the sexual history of the patient at the second visit led to the diagnosis, which was then confirmed with serological tests. Dermoscopy may become a supportive tool to facilitate the recognition of secondary syphilis; however, the reporting of these atypical cases is crucial to highlight the many faces of the disease so that clinicians consider syphilis as part of the differential diagnosis of non-specific lesions.
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