Evidence map›Paper›PMID 36672991›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Spinal Metastasis in a Patient with Supratentorial Glioblastoma with Primitive Neuronal Component: A Case Report with Clinical and Molecular Evaluation.

Michal Hendrych, Peter Solar, Marketa Hermanova, Ondrej Slaby, Hana Valekova, Marek Vecera, Alena Kopkova, Zdenek Mackerle, Tomas Kazda, Petr Pospisil and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Michal HendrychFirst Department of Pathology, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.ORCID 0000-0002-1024-7408
Peter SolarDepartment of Neurosurgery, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.ORCID 0000-0001-8958-613X
Marketa HermanovaFirst Department of Pathology, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.ORCID 0000-0002-3889-0905
Ondrej SlabyDepartment of Biology, Faculty of Medicine and Central European Institute of Technology (CEITEC), Masaryk University, 625 00 Brno, Czech Republic.
Hana ValekovaDepartment of Neurosurgery, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.
Marek VeceraCentral European Institute of Technology (CEITEC), Masaryk University, 625 00 Brno, Czech Republic.ORCID 0000-0001-7510-3694
Alena KopkovaCentral European Institute of Technology (CEITEC), Masaryk University, 625 00 Brno, Czech Republic.
Zdenek MackerleDepartment of Neurosurgery, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.
Tomas KazdaDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute Brno and Faculty of Medicine, Masaryk University, 656 53 Brno, Czech Republic.ORCID 0000-0001-7288-8975
Petr PospisilDepartment of Radiation Oncology, Masaryk Memorial Cancer Institute Brno and Faculty of Medicine, Masaryk University, 656 53 Brno, Czech Republic.
Radek LakomyDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk University, 656 53 Brno, Czech Republic.
Jan ChrastinaDepartment of Neurosurgery, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.
Jiri SanaCentral European Institute of Technology (CEITEC), Masaryk University, 625 00 Brno, Czech Republic.
Radim JancalekDepartment of Neurosurgery, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, 602 00 Brno, Czech Republic.ORCID 0000-0001-6834-6567
Masaryk University · CZCentral European Institute of Technology · CZ

Funding

Masaryk University MUNI/A/1408/2021Masaryk University MUNI/A/1645/2020Ministry of Education, Youth and Sports, Czech Republic INTER-EXCELLENCE, No. LTC20027
6 · The paper itself

Abstract

Glioblastoma (GBM) is regarded as an aggressive brain tumor that rarely develops extracranial metastases. Despite well-investigated molecular alterations in GBM, there is a limited understanding of these associated with the metastatic potential. We herein present a case report of a 43-year-old woman with frontal GBM with primitive neuronal component who underwent gross total resection followed by chemoradiation. Five months after surgery, the patient was diagnosed with an intraspinal GBM metastasis. Next-generation sequencing analysis of both the primary and metastatic GBM tissues was performed using the Illumina TruSight Tumor 170 assay. The number of single nucleotide variants observed in the metastatic sample was more than two times higher. Mutations in

Indexed as

ARID1AglioblastomametastasismutationNF1NOTCH3

Identifiers

PMID36672991
PMCPMC9858260
OpenAlexW4313500060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.