Evidence map›Paper›PMID 36672948›Full record

ArticleGenes2023

Comparative Genetic Association Analysis of Human Genetic Susceptibility to Pulmonary and Lymph Node Tuberculosis.

Abhimanyu, Mridula Bose, Astha Giri, Mandira Varma-Basil

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

AbhimanyuDepartment of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.ORCID 0000-0001-7888-8722
Mridula BoseDepartment of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.
Astha GiriDepartment of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.
Mandira Varma-BasilDepartment of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.ORCID 0000-0001-5562-015X
University of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) manifests itself primarily in the lungs as pulmonary disease (PTB) and sometimes disseminates to other organs to cause extra-pulmonary TB, such as lymph node TB (LNTB). This study aimed to investigate the role of host genetic polymorphism in immunity related genes to find a genetic basis for such differences.

methodsSixty-three, Single nucleotide polymorphisms (SNPs) in twenty-three, TB-immunity related genes including eleven innate immunity (

resultsPTB and LNTB showed differential genetic associations. The genetic variants in the cytokine genes (

conclusionsPTB and LNTB outcomes of TB infection have a genetic component and should be considered for any future functional studies or studies on susceptibility to pulmonary and extra-pulmonary TB.

Indexed as

Tuberculosis, Lymph NodeTuberculosis, PulmonaryCytokinesGenetic Predisposition to DiseaseHumansInterleukin-12Interleukin-4LungPolymorphism, Single NucleotideToll-Like Receptor 2CytokinesInterleukin-12Interleukin-4Toll-Like Receptor 2cytokineextra-pulmonary tuberculosisgenetic associationgenotypeinnate immunitylymph node tuberculosispulmonary tuberculosisserumsingle nucleotide polymorphisms

Identifiers

PMID36672948
PMCPMC9859508
OpenAlexW4315853275

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.