Evidence map›Paper›PMID 36672941›Full record

ArticleGenes2023

Epigenetic Repression of

Gokul Gopinathan, Xianghong Luan, Thomas G H Diekwisch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gokul GopinathanCenter for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA.
Xianghong LuanCenter for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA.
Thomas G H DiekwischDepartment of Oral and Craniofacial Sciences, University of Rochester School of Medicine and Dentistry, 625 Elmwood Avenue, Rochester, NY 14620, USA.ORCID 0000-0003-3356-9677
International Craniofacial Institute · USUniversity of Rochester · US

Funding

Neurological control of periodontal homeostasis through microRNA, TGF-beta, and Wnt signalingR01DE027930 · NIDCR · UNIVERSITY OF ROCHESTER · PI DIEKWISCH, TOM · 2018 to 2022
$1.8M
Small molecule mediated restoration of periodontal homeostasis through the YAP1 pathwayR01DE026198 · NIDCR · UNIVERSITY OF ROCHESTER · PI DIEKWISCH, TOM · 2017 to 2021
$1.7M
NIDCR NIH HHS DE026198, DE027930NIDCR NIH HHS R01 DE026198NIDCR NIH HHS R01 DE027930
6 · The paper itself

Abstract

The nonmineralized state of the mammalian periodontal ligament is one of the hallmarks of vertebrate evolution as it provides resilient and nontraumatic tooth anchorage for effective predation. Here we sought to determine how the chromatin state of key mineralization gene promoters contributes to the nonmineralized periodontal ligament in the midst of fully mineralized alveolar bone and cementum anchor tissues. In developing mouse periodontal tissues,

Indexed as

Epigenesis, GeneticPeriodontal LigamentAnimalsCore Binding Factor Alpha 1 SubunitEpigenetic RepressionMammalsMiceRatsSp7 Transcription FactorTranscription FactorsCore Binding Factor Alpha 1 SubunitRunx2 protein, mouseRunx2 protein, ratSp7 protein, mouseSp7 protein, ratSp7 Transcription FactorTranscription Factorshistone methylationmineralizationOSXperiodontalRUNX2

Identifiers

PMID36672941
PMCPMC9858805
OpenAlexW4315700496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.