Evidence map›Paper›PMID 36672920›Full record

ArticleGenes2023

Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study.

Daniel M Webber, Ming Li, Stewart L MacLeod, Xinyu Tang, Joseph W Levy, Mohammad A Karim, Stephen W Erickson, Charlotte A Hobbs, The National Birth Defects Prevention Study

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Discovery ofAmerican journal of translational research · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Daniel M WebberDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ming LiDepartment of Epidemiology and Biostatistics, Indiana University at Bloomington, Bloomington, IN 47405, USA.
Stewart L MacLeodDivision of Birth Defects Research, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Xinyu TangBiostatistics Program, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Joseph W LevyDepartment of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48202, USA.
Mohammad A KarimDepartment of Child Health, College of Medicine, University of Arizona, Phoenix, AZ 85004, USA.
Stephen W EricksonCenter for Genomics in Public Health and Medicine, RTI International, Research Triangle Park, NC 27709, USA.ORCID 0000-0001-7602-1770
Charlotte A HobbsRady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA 92123, USA.
The National Birth Defects Prevention Study
University of Arkansas for Medical Sciences · USBarrow Neurological Institute · USChildren’s Institute · USIndiana University Bloomington · USRTI International · USWashington University in St. Louis · USWayne State University · US

Funding

Genomic/Epigenomic Factors and Non-Syndromic Congenital Heart Defect Risk R01HD039054 · NICHD · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI HOBBS, CHARLOTTE A · 2000 to 2016
$13.6M
Random Field Modelling of genetic and epigenetic association underlying congenital heart defects in the presence of disease heterogeneityK01HL140333 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI LI, MING · 2018 to 2021
$724k
Gene-by-Gene and Gene-by-Environment Interactions Underlying Congenital Heart DefectsR03HD092854 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI LI, MING · 2018 to 2019
$171k
NHLBI NIH HHS K01 HL140333NICHD NIH HHS R01 HD039054NICHD NIH HHS R03 HD092854
6 · The paper itself

Abstract

Conotruncal heart defects (CTDs) are heart malformations that affect the cardiac outflow tract and typically cause significant morbidity and mortality. Evidence from epidemiological studies suggests that maternal folate intake is associated with a reduced risk of heart defects, including CTD. However, it is unclear if folate-related gene variants and maternal folate intake have an interactive effect on the risk of CTDs. In this study, we performed targeted sequencing of folate-related genes on DNA from 436 case families with CTDs who are enrolled in the National Birth Defects Prevention Study and then tested for common and rare variants associated with CTD. We identified risk alleles in maternal

Indexed as

Folic AcidHeart Defects, CongenitalFetusGenotypeHeartHumansFolic Acidcongenitalfolategene environmentheartMTHFSNBDPS

Identifiers

PMID36672920
PMCPMC9859210
OpenAlexW4313898679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.