Evidence map›Paper›PMID 36672914›Full record

ArticleGenes2023

SARS-CoV-2 Omicron Variant Genomic and Phylogenetic Analysis in Iraqi Kurdistan Region.

Sevan Omer Majed, Suhad Asad Mustafa, Paywast Jamal Jalal, Mohammed Hassan Fatah, Monika Miasko, Zanko Jawhar, Abdulkarim Yasin Karim

Open access · goldAbstract read
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Sevan Omer MajedBiology Department, College of Education, Salahaddin University-Erbil, Erbil 44001, Kurdistan Region, Iraq.
Suhad Asad MustafaGeneral Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil 44001, Kurdistan Region, Iraq.ORCID 0000-0002-6774-2979
Paywast Jamal JalalBiology Department, College of Science, University of Sulaimani, Sulaymaniyah 46001, Kurdistan Region, Iraq.ORCID 0000-0002-7498-532X
Mohammed Hassan FatahMedical Lab., Technology Department, Kalar Technical College, Sulaimani Polytechnic University, Kalar 46021, Kurdistan Region, Iraq.ORCID 0000-0001-6366-4216
Monika MiaskoMedical Analysis Department, Faculty of Applied Science, Tishk International University, Erbil 44001, Kurdistan Region, Iraq.
Zanko JawharMedical Laboratory Science, College of Health Sciences, Lebanese French University, Erbil 44001, Kurdistan Region, Iraq.
Abdulkarim Yasin KarimDepartment of Biology, College of Science, Salahaddin University-Erbil, Erbil 44001, Kurdistan Region, Iraq.ORCID 0000-0002-8829-9769
Salahaddin University-Erbil · IQCihan University-Erbil · IQLebanese French University · IQSulaimani Polytechnic University · IQTishk International University · IQUniversity of Sulaimani · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Omicron variants have been classified as Variants of Concern (VOC) by the World Health Organization (WHO) ever since they first emerged as a result of a significant mutation in this variant, which showed to have an impact on transmissibility and virulence of the virus, as evidenced by the ongoing modifications in the SARS-CoV-2 virus. As a global pandemic, the Omicron variant also spread among the Kurdish population. This study aimed to analyze different strains from different cities of the Kurdistan region of Iraq to show the risk of infection and the impact of the various mutations on immune responses and vaccination. A total of 175 nasopharyngeal/oropharyngeal specimens were collected at West Erbil Emergency Hospital and confirmed for SARS-CoV-2 infection by RT-PCR. The genomes of the samples were sequenced using the Illumina COVID-Seq Method. The genome analysis was established based on previously published data in the GISAID database and compared to previously detected mutations in the Omicron variants, and that they belong to the BA.1 lineage and include most variations determined in other studies related to transmissibility, high infectivity and immune escape. Most of the mutations were found in the RBD (receptor binding domain), the region related to the escape from humoral immunity. Remarkably, these point mutations (G339D, S371L, S373P, S375F, T547K, D614G, H655Y, N679K and N969K) were also determined in this study, which were unique, and their impact should be addressed more. Overall, the Omicron variants were more contagious than other variants. However, the mortality rate was low, and most infectious cases were asymptomatic. The next step should address the potential of Omicron variants to develop the next-generation COVID-19 vaccine.

Indexed as

COVID-19SARS-CoV-2COVID-19 VaccinesGenomicsHumansIraqPhylogenyCOVID-19 VaccinesGISAIDIllumina COVID-eq methodOmicronreceptor binding domainSARS-CoV-2Variants of Concern

Identifiers

PMID36672914
PMCPMC9859166
OpenAlexW4313891075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.