Evidence map›Paper›PMID 36672866›Full record

ArticleGenes2023

Twins' Macular Pigment Optical Density Assessment and Relation with SCARB1 Gene Polymorphism.

Edita Kunceviciene, Ruta Mockute, Aiste Petrauskaite, Brigita Budiene, Alina Smalinskiene, Ieva Zvykaite, Rasa Liutkeviciene

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. "Characterization of visual function parameters in relation to macular pigment optical density in a pediatric population".Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Edita KuncevicieneInstitute of Biology Systems and Genetics Research, Lithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.ORCID 0000-0002-0423-7318
Ruta MockuteDepartment of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50161 Kaunas, Lithuania.
Aiste PetrauskaiteDepartment of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50161 Kaunas, Lithuania.
Brigita BudieneDepartment of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50161 Kaunas, Lithuania.
Alina SmalinskieneInstitute of Biology Systems and Genetics Research, Lithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.ORCID 0000-0001-8816-3995
Ieva ZvykaiteInstitute of Biology Systems and Genetics Research, Lithuanian University of Health Sciences, Tilzes 18, 47181 Kaunas, Lithuania.
Rasa LiutkevicieneDepartment of Ophthalmology, Lithuanian University of Health Sciences, Eiveniu 2, 50161 Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

the aim of the studyto assess the influence of genetic and environmental factors using twin studies and evaluate the associations of SCARB1 gene variants (rs11057841) with AMD and MPOD. MATERIAL AND

methodsa total of 108 healthy twins (56 MZ and 52 DZ twins) were tested in this study. The MPOD was measured using the one-wavelength reflectometry method. Fundus reflectance (Visucam 500, reflectance of a single 460 nm wavelength) was used to measure the MPOD levels, MPOD parameters including max and mean optical density (OD), and area and volume. Real-time polymerase chain reaction was used to detect single nucleotide polymorphisms.

resultswe detected a positive correlation of MPOD in the right and left eyes in MZ twin pairs (r = 0.830 and r = 0.860, respectively) (

conclusionthis twin study showed a strong heritability of the retina pigment, which was 86% prevalent in Lithuania. Individuals with a CT genotype of the SCARB1 rs11057841 with a risk allele had statistically significantly lower mean MPOD values in both eyes compared to subjects with a wild-type CC genotype.

Indexed as

Macular PigmentFundus OculiGenotypeHumansPolymorphism, Single NucleotideScavenger Receptors, Class BTwinsMacular PigmentSCARB1 protein, humanScavenger Receptors, Class Bdizygotic twinsmacular pigment optical densitymonozygotic twinsSCARB1

Identifiers

PMID36672866
PMCPMC9858834
OpenAlexW4313427736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.