Evidence map›Paper›PMID 36672863›Full record

ArticleGenes2023

Altered Left Ventricular Rat Gene Expression Induced by the Myosin Activator Omecamtiv Mecarbil.

Bachar El Oumeiri, Laurence Dewachter, Philippe Van de Borne, Géraldine Hubesch, Christian Melot, Pascale Jespers, Constantin Stefanidis, Kathleen Mc Entee, Frédéric Vanden Eynden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Frontiers in cellular and infection microbiology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bachar El OumeiriDepartment of Cardiac Surgery, Université Libre de Bruxelles (ULB) Erasme University Hospital, 1070 Brussels, Belgium.ORCID 0000-0002-5955-0547
Laurence DewachterLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Philippe Van de BorneDepartment of Cardiology, Université Libre de Bruxelles (ULB) Erasme University Hospital, 1070 Brussels, Belgium.ORCID 0000-0002-5693-1045
Géraldine HubeschLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Christian MelotLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.ORCID 0000-0002-6172-0330
Pascale JespersLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Constantin StefanidisDepartment of Cardiac Surgery, Université Libre de Bruxelles (ULB) Erasme University Hospital, 1070 Brussels, Belgium.
Kathleen Mc EnteeLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
Frédéric Vanden EyndenDepartment of Cardiac Surgery, Université Libre de Bruxelles (ULB) Erasme University Hospital, 1070 Brussels, Belgium.
Université Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the impact of omecamtiv mecarbil (OM) on the gene expression profile in adult male rats. Fourteen male Wistar rats were randomly assigned to a single OM (1.2 mg/kg/h; n = 6) or placebo (n = 8) 30-min infusion. Echocardiography was performed before and after OM infusion. Seven days after infusion, rats were euthanized, and left ventricular (LV) tissues were removed for

Indexed as

CalciumMyosinsAnimalsbcl-2-Associated X ProteinCalcium Channels, L-TypeGene ExpressionMaleRatsRats, WistarSerine EndopeptidasesUreabcl-2-Associated X ProteinCacna1c protein, ratCalciumCalcium Channels, L-TypeKlk8 protein, ratMyosinsomecamtiv mecarbilSerine EndopeptidasesUreaapoptosisgene expressionleft ventriclemetabolismomecamtiv mecarbiloxidative stress

Identifiers

PMID36672863
PMCPMC9858687
OpenAlexW4313472805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.