Evidence map›Paper›PMID 36672812›Full record

ArticleGenes2022

Predicting Genetic Disorder and Types of Disorder Using Chain Classifier Approach.

Ali Raza, Furqan Rustam, Hafeez Ur Rehman Siddiqui, Isabel de la Torre Diez, Begoña Garcia-Zapirain, Ernesto Lee, Imran Ashraf

Abstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ali RazaDepartment of Computer Science, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan 64200, Pakistan.ORCID 0000-0001-5429-9835
Furqan RustamSchool of Computer Science, University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0000-0001-8403-1047
Hafeez Ur Rehman SiddiquiDepartment of Computer Science, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan 64200, Pakistan.ORCID 0000-0003-0671-2060
Isabel de la Torre DiezDepartment of Signal Theory and Communications and Telematic Engineering, University of Valladolid, Paseo de Belén 15, 47011 Valladolid, Spain.ORCID 0000-0003-3134-7720
Begoña Garcia-ZapirainDepartment of Computer Science, Electronics and Telecommunications, University of Deusto, 48007 Bilbao, Spain.ORCID 0000-0002-9356-1186
Ernesto LeeCollege of Engineering and Technology, Miami Dade College, Miami, FL 33132, USA.
Imran AshrafDepartment of Information and Communication Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.ORCID 0000-0002-8271-6496

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic disorders are the result of mutation in the deoxyribonucleic acid (DNA) sequence which can be developed or inherited from parents. Such mutations may lead to fatal diseases such as Alzheimer's, cancer, Hemochromatosis, etc. Recently, the use of artificial intelligence-based methods has shown superb success in the prediction and prognosis of different diseases. The potential of such methods can be utilized to predict genetic disorders at an early stage using the genome data for timely treatment. This study focuses on the multi-label multi-class problem and makes two major contributions to genetic disorder prediction. A novel feature engineering approach is proposed where the class probabilities from an extra tree (ET) and random forest (RF) are joined to make a feature set for model training. Secondly, the study utilizes the classifier chain approach where multiple classifiers are joined in a chain and the predictions from all the preceding classifiers are used by the conceding classifiers to make the final prediction. Because of the multi-label multi-class data, macro accuracy, Hamming loss, and

Indexed as

Artificial IntelligenceNeoplasmsHumansPrognosisRandom Forestchain classifier approachgenetic disordergenome mutationmachine learning

Identifiers

PMID36672812
PMCPMC9858679

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.