Evidence map›Paper›PMID 36672803›Full record

ArticleGenes2022

Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium.

Huichun Xu, Kevin Nguyen, Brady J Gaynor, Hua Ling, Wei Zhao, Patrick F McArdle, Timothy D O'Connor, O Colin Stine, Kathleen A Ryan, Megan Lynch and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 5 institutions in 1 country.

Huichun XuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-8118-9607
Kevin NguyenDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Brady J GaynorDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Hua LingCenter for Inherited Disease Research, Dept. of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4032-5745
Patrick F McArdleDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Timothy D O'ConnorDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
O Colin StineDepartment of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kathleen A RyanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-1158-8455
Megan LynchDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3575-5468
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA.
Yao HuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Jeffrey W HaesslerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
On Behalf Of The Trans-Omics For Precision Medicine TOPMed Stroke Working Group
James A PerryDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-5050-2074
Charles C HongDepartment of Cardiology Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0424-8252
John W ColeDepartment of Neurology Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Elizabeth PughCenter for Inherited Disease Research, Dept. of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kimberly DohenyCenter for Inherited Disease Research, Dept. of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-8806-5738
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA.
Steven J KittnerDepartment of Neurology Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-4920-4744
SiGN Consortium
University of Maryland, Baltimore · USUniversity of Michigan · USFred Hutch Cancer Center · USJohns Hopkins University · USThe University of Texas Health Science Center at Houston · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
Genetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0M
Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
Novel Approach to Enhance Myocardial Performance and Improve Heart Failure OutcomeR01HL135129 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HONG, CHARLES C · 2018 to 2021
$1.6M
BLRD VA I01 BX004672Medical Research Council MC_PC_17228NHLBI NIH HHS R01 HL135129NIA NIH HHS P30 AG028747NIA NIH HHS U01 AG009740NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS R01 NS114045
6 · The paper itself

Abstract

Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we performed an exome array analysis on 106,101 SNPs for 9721 ischemic stroke cases from the SiGN Consortium, and 12,345 subjects with no history of stroke from the Health Retirement Study and SiGN consortium. We identified 15 coding variants significantly associated with all ischemic stroke at array-wide threshold (i.e.,

Indexed as

Ischemic StrokeStrokeExomeGene FrequencyGenome-Wide Association StudyHumansAfrican Americanexome arrayexome wide association studyischemic strokerare coding variants

Identifiers

PMID36672803
PMCPMC9858999
OpenAlexW4313244997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.