Evidence map›Paper›PMID 36672800›Full record

SynthesisGenes2022

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study.

Ekaterina Orlova, Tom Dudding, Jonathan M Chernus, Rasha N Alotaibi, Simon Haworth, Richard J Crout, Myoung Keun Lee, Nandita Mukhopadhyay, Eleanor Feingold, Steven M Levy and 6 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Bacterial community modifies host genetics effect on early childhood caries.medRxiv : the preprint server for health sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Ekaterina OrlovaDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Tom DuddingBristol Dental School, University of Bristol, Bristol BS1 2LY, UK.
Jonathan M ChernusDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Rasha N AlotaibiDental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh 12372, Saudi Arabia.
Simon HaworthBristol Dental School, University of Bristol, Bristol BS1 2LY, UK.ORCID 0000-0001-7793-7326
Richard J CroutDepartment of Periodontics, School of Dentistry, West Virginia University, Morgantown, WV 26505, USA.
Myoung Keun LeeCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Nandita MukhopadhyayCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Eleanor FeingoldDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Steven M LevyDepartment of Preventive & Community Dentistry, University of Iowa College of Dentistry, Iowa City, IA 52242, USA.
Daniel W McNeilDepartment of Psychology & Department of Dental Public Health and Professional Practice, West Virginia University, Morgantown, WV 26505, USA.
Betsy FoxmanCenter for Molecular and Clinical Epidemiology of Infectious Diseases, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6682-238X
Robert J WeyantDental Public Health, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Nicholas J TimpsonMedical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, University of Bristol, Bristol BS8 1QU, UK.
Mary L MarazitaDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-2648-2832
John R ShafferDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0003-1897-1131
University of Pittsburgh · USUniversity Of Bristol Dental Hospital · GBWest Virginia University · USKing Saud University · SAUniversity of Bristol · GBUniversity of Iowa · USUniversity of Michigan · US

Funding

Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
LONGITUDINAL STUDY OF FLUORIDE EXPOSURES &FLUORIDER01DE009551 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1991 to 2008
$4.7M
Dental Caries: Whole Genome Association and Gene x Environment StudiesU01DE018903 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2007 to 2010
$1.2M
PILOT STUDIESP30DE010126 · NIDCR · UNIVERSITY OF IOWA · PI SQUIER, CHRISTOPHER · 1991 to 2001
$745k
NIDCR NIH HHS R01 DE009551NIDCR NIH HHS R01 DE014899NIDCR NIH HHS U01 DE018903NIH HHS 1-U01-DE018903NIH HHS P30-DE10126NIH HHS R01-DE014899NIH HHS R01-DE09551NIH HHS X01-HG009878Wellcome TrustWellcome Trust 217065/Z/19/Z
6 · The paper itself

Abstract

Although genetics affects early childhood caries (ECC) risk, few studies have focused on finding its specific genetic determinants. Here, we performed genome-wide association studies (GWAS) in five cohorts of children (aged up to 5 years, total N = 2974, cohorts: Center for Oral Health Research in Appalachia cohorts one and two [COHRA1, COHRA2], Iowa Fluoride Study, Iowa Head Start, Avon Longitudinal Study of Parents and Children [ALSPAC]) aiming to identify genes with potential roles in ECC biology. We meta-analyzed the GWASs testing ~3.9 million genetic variants and found suggestive evidence for association at genetic regions previously associated with caries in primary and permanent dentition, including the β-defensin anti-microbial proteins. We then integrated the meta-analysis results with gene expression data in a transcriptome-wide association study (TWAS). This approach identified four genes whose genetically predicted expression was associated with ECC (p-values < 3.09 × 10−6; CDH17, TAS2R43, SMIM10L1, TAS2R14). Some of the strongest associations were with genes encoding members of the bitter taste receptor family (TAS2R); other members of this family have previously been associated with caries. Of note, we identified the receptor encoded by TAS2R14, which stimulates innate immunity and anti-microbial defense in response to molecules released by the cariogenic bacteria, Streptococcus mutans and Staphylococcus aureus. These findings provide insight into ECC genetic architecture, underscore the importance of host-microbial interaction in caries risk, and identify novel risk genes.

Indexed as

Genome-Wide Association StudyTasteAgedChildChild, PreschoolDental Caries SusceptibilityHumansLongitudinal StudiesStreptococcus mutansTranscriptomechildgeneticsmolecular epidemiologyoral health

Identifiers

PMID36672800
PMCPMC9858612
OpenAlexW4313245023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.