Evidence map›Paper›PMID 36672680›Full record

ArticleBiomedicines2023

Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells.

Basappa Basappa, Lisha K Poonacha, Zhang Xi, Divakar Vishwanath, Ji-Rui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 5 countries.

Basappa BasappaLaboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.ORCID 0000-0002-8844-468X
Lisha K PoonachaDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
Zhang XiShenzhen Bay Laboratory, Shenzhen 518107, China.ORCID 0000-0003-4093-0897
Divakar VishwanathLaboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.ORCID 0000-0001-7453-0918
Ji-Rui YangTsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-2224-7648
Omantheswara NagarajaDepartment of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.
Ananda SwamynayakaDepartment of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.ORCID 0000-0003-3146-5188
Mahendra MadegowdaDepartment of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570006, India.ORCID 0000-0002-8543-1947
Arunachalam ChinnathambiDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5075-5901
Sulaiman Ali AlharbiDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Doddahosuru Mahadevappa GurudattLaboratory of Chemical Biology, Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
Vijay PandeyTsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 100084, China.ORCID 0000-0001-8704-0694
Nanjundaswamy ShivananjuDepartment of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS, Technical Institutions Campus, Mysore 570006, India.
Kwang Seok AhnKHU-KIST Department of Converging Science and Technology, Kyung Hee University, 24 Kyungheedaero, Dongdaemun-gu, Seoul 02447, Republic of Korea.ORCID 0000-0002-2882-0612
Gautam SethiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Peter E LobieShenzhen Bay Laboratory, Shenzhen 518107, China.
Priya Babu ShubhaDepartment of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India.
University of Mysore · INKing Saud University · SAShenzhen Bay Laboratory · CNTsinghua–Berkeley Shenzhen Institute · CNKyung Hee University · KRNational University of Singapore · SG

Funding

Department of Biotechnology NER-BASAPPA/2018Department of Science and Technology 637/2019
6 · The paper itself

Abstract

Small molecules are being used to inhibit cyclin dependent kinase (CDK) enzymes in cancer treatment. There is evidence that CDK is a drug-target for cancer therapy across many tumor types because it catalyzes the transfer of the terminal phosphate of ATP to a protein that acts as a substrate. Herein, the identification of pyranopyrazoles that were CDK inhibitors was attempted, whose synthesis was catalyzed by nano-zirconium dioxide via multicomponent reaction. Additionally, we performed an in-situ analysis of the intermediates of multicomponent reactions, for the first-time, which revealed that nano-zirconium dioxide stimulated the reaction, as estimated by Gibbs free energy calculations of spontaneity. Functionally, the novel pyranopyrazoles were tested for a loss of cell viability using human breast cancer cells (MCF-7). It was observed that compounds

Indexed as

CDK1CHEMBLGibbs free energynano-zirconium dioxidepyranopyrazoles

Identifiers

PMID36672680
PMCPMC9856062
OpenAlexW4315567711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.