Evidence map›Paper›PMID 36672610›Full record

ArticleBiomedicines2022

Functional Validation of the Putative Oncogenic Activity of

Federica Sarno, Désirée Goubert, Emilie Logie, Martijn G S Rutten, Mihaly Koncz, Christophe Deben, Anita E Niemarkt, Lucia Altucci, Pernette J Verschure, Antal Kiss and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Subtype-Independent Activation of NF-κB Signaling in Breast Cancer.International journal of molecular sciences · 2026
    Article
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  12. IdentifyingFrontiers in cardiovascular medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Federica SarnoEpigenetic Editing, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Désirée GoubertEpigenetic Editing, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Emilie LogieCenter for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), Laboratory of Protein Chemistry, Proteomics and Epigenetic Signalling (PPES), Department of Biomedical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.
Martijn G S RuttenEpigenetic Editing, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-4640-1830
Mihaly KonczSwammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
Christophe DebenCenter for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0001-8085-2040
Anita E NiemarktEpigenetic Editing, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Lucia AltucciDepartment of Precision Medicine, Universita' degli Studi della Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-7312-5387
Pernette J VerschureSwammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0003-2922-4836
Antal KissInstitute of Biochemistry, Biological Research Centre, H-6726 Szeged, Hungary.ORCID 0000-0002-7975-3085
Wim Vanden BergheCenter for Oncological Research (CORE), Integrated Personalized & Precision Oncology Network (IPPON), Laboratory of Protein Chemistry, Proteomics and Epigenetic Signalling (PPES), Department of Biomedical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0003-0161-7355
Marianne G RotsEpigenetic Editing, Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-7416-2788
University Medical Center Groningen · NLUniversity of Antwerp · BEHUN-REN Szegedi Biológiai Kutatóközpont · HUUniversity of Amsterdam · NLUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Szeged · HU

Funding

European Union H2020-MSCA-ITN-2014-ETN EpiPredict 642691Foundation Against Cancer (Belgium) 7872Research Foundation Flanders (Belgium) FWO G1179120N, G059713N
6 · The paper itself

Abstract

Plasminogen activator, urokinase (

Indexed as

CRISPR-dCas9Epigenetic EditingoncogenePLAUtriple negative breast cancer

Identifiers

PMID36672610
PMCPMC9856075
OpenAlexW4313472226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.