Evidence map›Paper›PMID 36672542›Full record

ArticleBiomedicines2022

Combined Transcutaneous Electrical Spinal Cord Stimulation and Task-Specific Rehabilitation Improves Trunk and Sitting Functions in People with Chronic Tetraplegia.

Niraj Singh Tharu, Monzurul Alam, Yan To Ling, Arnold Yl Wong, Yong-Ping Zheng

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527417 (The Effect of Electromyography Triggered Electrical Stimulation on Trunk Balance and Muscle Thickness of Multifidus and Erector Spinae Muscles in Patients With Complete Spinal Cord Injury - A Randomised Controlled Study), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06527417 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Electromyography Triggered Electrical Stimulation on Trunk Balance and Muscle Thickness of Multifidus and Erector Spinae Muscles in Patients With Complete Spinal Cord Injury - A Randomised Controlled Study

TypeinterventionalSponsorAnkara City Hospital BilkentRan2023 to 2024Enrolled15ConditionsSpinal Cord Injury ThoracicArmsNeuro Trac Myo Plus Pro, Trunk eccentric exercises
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  7. [A simulation study of nerve fiber activation in the lumbar segment under kilohertz-frequency transcutaneously spinal cord stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
  8. Review
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  12. Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Niraj Singh TharuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID 0000-0002-6320-3329
Monzurul AlamDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID 0000-0003-0987-1999
Yan To LingDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID 0000-0003-2443-1561
Arnold Yl WongDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID 0000-0002-5911-5756
Yong-Ping ZhengDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID 0000-0002-3407-9226
Hong Kong Polytechnic University · HK

Funding

The work was supported by The Hong Kong Polytechnic University (UAKB) and the Telefield Charitable Fund (ZH3V) ZH3V
6 · The paper itself

Abstract

The aim of this study was to examine the effects of transcutaneous electrical spinal cord stimulation (TSCS) and conventional task-specific rehabilitation (TSR) on trunk control and sitting stability in people with chronic tetraplegia secondary to a spinal cord injury (SCI). Five individuals with complete cervical (C4-C7) cord injury participated in 24-week therapy that combined TSCS and TSR in the first 12 weeks, followed by TSR alone for another 12 weeks. The TSCS was delivered simultaneously at T11 and L1 spinal levels, at a frequency ranging from 20-30 Hz with 0.1-1.0 ms. pulse width biphasically. Although the neurological prognosis did not manifest after either treatment, the results show that there were significant increases in forward reach distance (10.3 ± 4.5 cm), right lateral reach distance (3.7 ± 1.8 cm), and left lateral reach distance (3.0 ± 0.9 cm) after the combinational treatment (TSCS+TSR). The stimulation also significantly improved the participants' trunk control and function in sitting. Additionally, the trunk range of motion and the electromyographic response of the trunk muscles were significantly elevated after TSCS+TSR. The TSCS+TSR intervention improved independent trunk control with significantly increased static and dynamic sitting balance, which were maintained throughout the TSR period and the follow-up period, indicating long-term sustainable recovery.

Indexed as

sitting balancespinal cord injurytetraplegiatranscutaneous electrical spinal cord stimulationtrunk control

Identifiers

PMID36672542
PMCPMC9855778
OpenAlexW4313260854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.