Evidence map›Paper›PMID 36672540›Full record

ReviewBiomedicines2022

Tumor Biology and Microenvironment of Vestibular Schwannoma-Relation to Tumor Growth and Hearing Loss.

Michaela Tesařová, Lenka Peterková, Monika Šťastná, Michal Kolář, Lukáš Lacina, Karel Smetana, Radovan Hynek, Jan Betka, Aleš Vlasák, Petr Lukeš and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Michaela TesařováDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Lenka PeterkováDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Monika ŠťastnáInstitute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Michal KolářInstitute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.ORCID 0000-0002-4593-1525
Lukáš LacinaInstitute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.ORCID 0000-0002-1750-9933
Karel SmetanaInstitute of Anatomy, 1st Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.ORCID 0000-0002-7878-8403
Radovan HynekInstitute of Biochemistry and Microbiology, University of Chemistry and Technology, 166 28 Prague, Czech Republic.
Jan BetkaDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Aleš VlasákDepartment of Neurosurgery, 2nd Faculty of Medicine, Charles University, 150 06 Prague, Czech Republic.ORCID 0000-0002-5724-006X
Petr LukešDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.
Zdeněk FíkDepartment of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and Motol University Hospital, 150 06 Prague, Czech Republic.ORCID 0000-0003-4243-9727
Charles University · CZCzech Academy of Sciences · CZUniversity of Chemistry and Technology, Prague · CZ

Funding

Centre for tumour ecology CZ.02.1.01/0.0/0.0/16_019/0000785Charles University 874120Czech Science Foundation 19-08241S
6 · The paper itself

Abstract

Vestibular schwannoma is the most common benign neoplasm of the cerebellopontine angle. It arises from Schwann cells of the vestibular nerve. The first symptoms of vestibular schwannoma include hearing loss, tinnitus, and vestibular symptoms. In the event of further growth, cerebellar and brainstem symptoms, along with palsy of the adjacent cranial nerves, may be present. Although hearing impairment is present in 95% of patients diagnosed with vestibular schwannoma, most tumors do not progress in size or have low growth rates. However, the clinical picture has unpredictable dynamics, and there are currently no reliable predictors of the tumor's behavior. The etiology of the hearing loss in patients with vestibular schwannoma is unclear. Given the presence of hearing loss in patients with non-growing tumors, a purely mechanistic approach is insufficient. A possible explanation for this may be that the function of the auditory system may be affected by the paracrine activity of the tumor. Moreover, initiation of the development and growth progression of vestibular schwannomas is not yet clearly understood. Biallelic loss of the

Indexed as

hearing losstumor growthtumor microenvironmentVS

Identifiers

PMID36672540
PMCPMC9856152
OpenAlexW4312175619

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.