Evidence map›Paper›PMID 36672356›Full record

ArticleCancers2023

Diagnostic and Therapeutic Pathway of Advanced Ovarian Cancer with Peritoneal Metastases.

Valentina Ghirardi, Anna Fagotti, Luca Ansaloni, Mario Valle, Franco Roviello, Lorena Sorrentino, Fabio Accarpio, Gianluca Baiocchi, Lorenzo Piccini, Michele De Simone and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Surgery in ovarian cancer patients older than 70 years of age and frailty assessment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Function of mCancer biology & therapy · 2023
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Valentina GhirardiUOC Ginecologia Oncologica, Dipartimento per la Salute della Donna e del Bambino e della Salute Pubblica, Fondazione Policlinico Universitario a Gemelli (IRCCS), Catholic University of Sacred Heart, 00167 Rome, Italy.
Anna FagottiUOC Ginecologia Oncologica, Dipartimento per la Salute della Donna e del Bambino e della Salute Pubblica, Fondazione Policlinico Universitario a Gemelli (IRCCS), Catholic University of Sacred Heart, 00167 Rome, Italy.
Luca AnsaloniUnit of General Surgery, San Matteo Hospital, 27100 Pavia, Italy.
Mario VallePeritoneal Tumours Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Franco RovielloUnit of General Surgery and Surgical Oncology, Department of Medicine, Surgery, and Neurosciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-4122-1259
Lorena SorrentinoSC Chirurgia Generale d'Urgenza ed Oncologica, AOU Policlinico di Modena, 41124 Modena, Italy.
Fabio AccarpioCRS and HIPEC Unit, Pietro Valdoni, Umberto I Policlinico di Roma, 00161 Roma, Italy.
Gianluca BaiocchiDepartment of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili, 25123 Brescia, Italy.ORCID 0000-0003-2402-2178
Lorenzo PicciniGeneral and Peritoneal Surgery, Department of Surgery, Pisa University Hospital, 56100 Pisa, Italy.
Michele De SimoneCandiolo Cancer Institute, FPO-IRCCS, Candiolo, 10060 Torino, Italy.
Federico CoccoliniGeneral, Emergency and Trauma Surgery, Pisa University Hospital, 56100 Pisa, Italy.
Mario VisalocoU.O.C Pronto Soccorso Generale. Con O.B.I., Azienda Ospedaliera Universitaria "G. Martino", 98124 Messina, Italy.
Stefano BacchettiAOUD Center Advanced Surgical Oncology, DAME University of Udine, 33100 Udine, Italy.
Giovanni ScambiaUOC Ginecologia Oncologica, Dipartimento per la Salute della Donna e del Bambino e della Salute Pubblica, Fondazione Policlinico Universitario a Gemelli (IRCCS), Catholic University of Sacred Heart, 00167 Rome, Italy.
Daniele MarrelliUnit of General Surgery and Surgical Oncology, Department of Medicine, Surgery, and Neurosciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2066-1618
Agostino Gemelli University Polyclinic · ITUniversity of Siena · ITAzienda Ospedaliera Universitaria Pisana · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITAzienda Ospedaliero-Universitaria di Modena · ITCandiolo Cancer Institute · ITPoliclinico Umberto I · ITTumour Institute of Tuscany · ITUniversity of Brescia · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over two thirds of ovarian cancer patients present with advanced stage disease at the time of diagnosis. In this scenario, standard treatment includes a combination of cytoreductive surgery and carboplatinum-paclitaxel-based chemotherapy. Despite the survival advantage of patients treated with upfront cytoreductive surgery compared to women undergoing neo-adjuvant chemotherapy (NACT) and interval debulking surgery (IDS) due to high tumor load or poor performance status has been demonstrated by multiple studies, this topic is still a matter of debate. As a consequence, selecting the adequate treatment through an appropriate diagnostic pathway represents a crucial step. Aiming to assess the likelihood of leaving no residual disease at the end of surgery, the role of the CT scan as a predictor of cytoreductive outcomes has shown controversial results. Similarly, CA 125 level as an expression of tumor load demonstrated limited applicability. On the contrary, laparoscopic assessment of disease distribution through a validated scoring system was able to identify, with the highest specificity, patients undergoing suboptimal cytoreduction and therefore best suitable for NACT-IDS. Against this background, with this article, we aim to provide a comprehensive review of available evidence on the diagnostic and treatment pathways of advanced ovarian cancer.

Indexed as

debulking surgerydiagnosisneo-adjuvant chemotherapyovarian cancertreatment pathway

Identifiers

PMID36672356
PMCPMC9856580
OpenAlexW4313890664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.