ArticleCells2023
Skeletal Muscle DNA Methylation and mRNA Responses to a Bout of Higher versus Lower Load Resistance Exercise in Previously Trained Men.
Open access · goldAbstract read
In one paragraph
Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025Pooled it
- Research into resistance training response heterogeneity: a summary of the 2025 conference at the University of Jyväskylä.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Review
- Skeletal muscle mitochondrial marker responses to a single bout and 6 weeks of high load versus high volume resistance training in previously trained men.Experimental physiology · 2026Article
- Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Systemic Integrative Mechanisms and Intervention Strategies in Exercise-Induced Skeletal Muscle Damage: Evidence from Animal, Clinical, and Multi-Omics Studies.International journal of molecular sciences · 2026Review
- Training Load Oscillation and Epigenetic Plasticity: Molecular Pathways Connecting Energy Metabolism and Athletic Personality.International journal of molecular sciences · 2026Review
- Lactate as a metabolic-epigenetic signal linking high-intensity interval training (HIIT) to miRNA-Centered remodeling of the skeletal muscle methylome and transcriptome.Redox biology · 2025Article
- Epigenetic Changes Associated With Obesity-related Metabolic Comorbidities.Journal of the Endocrine Society · 2025Review
- Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise.Genome research · 2025Article
- A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review.American journal of physiology. Cell physiology · 2025Review
- Dnmt3a overexpression disrupts skeletal muscle homeostasis, promotes an aging-like phenotype, and reduces metabolic elasticity.iScience · 2025Article
- Comparative analysis of acute eccentric contraction-induced changes to the skeletal muscle transcriptome in young and aged mice and humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- An Integrated Neuromuscular Training Intervention Applied in Primary School Induces Epigenetic Modifications in Disease-Related Genes: A Genome-Wide DNA Methylation Study.Scandinavian journal of medicine & science in sports · 2025Article
- Time-series transcriptomics reveals distinctive mRNA expression dynamics associated with gene ontology specificity and protein expression in skeletal muscle after electrical stimulation-induced resistance exercise.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Skeletal muscle myosin heavy chain fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy.Experimental physiology · 2024Article
- Molecular aspects of the exercise response and training adaptation in skeletal muscle.Free radical biology & medicine · 2024Review
- Relative rDNA copy number is not associated with resistance training-induced skeletal muscle hypertrophy and does not affect myotube anabolism in vitro.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures.Cell genomics · 2024Article
- DNA Methylation in the Adaptive Response to Exercise.Sports medicine (Auckland, N.Z.) · 2024Review
- Skeletal muscle myosin heavy chain protein fragmentation as a potential marker of protein degradation in response to resistance training and disuse atrophy.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 2 countries.
Casey L SextonSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Joshua S GodwinSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Mason C McIntoshSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Bradley A RupleSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Shelby C OsburnSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Blake R HollingsworthSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Nicholas J KontosSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Philip J AgostinelliSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-0613-1031
Andreas N KavazisSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Tim N ZiegenfussThe Center for Applied Health Sciences, Canfield, OH 44406, USA.
Hector L LopezThe Center for Applied Health Sciences, Canfield, OH 44406, USA.
Ryan SmithTruDiagnostic, Lexington, KY 40503, USA.ORCID 0000-0001-7362-8753
Kaelin C YoungSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Varun B DwarakaTruDiagnostic, Lexington, KY 40503, USA.
Andrew D FrugéCollege of Nursing, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0001-9119-1380
Christopher B MobleySchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.
Adam P SharplesInstitute for Physical Performance, Norwegian School of Sport Sciences, 0863 Oslo, Norway.ORCID 0000-0003-1526-9400
Michael D RobertsSchool of Kinesiology, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-7359-5362
Auburn University · USNorwegian School of Sport Sciences · NO
Funding
G-RISE at Auburn UniversityT32GM141739 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI CLAYTON, TAFFYE BENSON, RUSSELL, MELODY L · 2021 to 2024
$1.2MNIGMS NIH HHS T32 GM141739NIH HHS T32GM141739
Abstract
We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower load (LL) versus higher load (HL) resistance exercise. Trained college-aged males (
Indexed as
DNA MethylationResistance TrainingAdultDNAHumansMaleMuscle, SkeletalPhosphatidylinositol 3-KinasesRNA, MessengerYoung AdultDNAPhosphatidylinositol 3-KinasesRNA, MessengerDNA methylationresistance exercisetraining volumetranscriptomics
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.