Evidence map›Paper›PMID 36672185›Full record

ArticleCells2023

Cord Blood Plasma and Placental Mesenchymal Stem Cells-Derived Exosomes Increase Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem Cells While Maintaining Their Stemness.

Rasha S Teleb, Amal Abdul-Hafez, Amira Othman, Ahmed El-Abd Ahmed, Abdelrahman A Elsaid, Hattan Arif, Ahmed A Zarea, Mohammed Abdulmageed, Hend Mohamed, Sherif Abdelfattah Ibrahim and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Rasha S TelebDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Amal Abdul-HafezDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-2895-7862
Amira OthmanDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Ahmed El-Abd AhmedDepartment of Pediatrics and Neonatology, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
Abdelrahman A ElsaidClinical Pathology Department, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
Hattan ArifDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Ahmed A ZareaThe Institute for Quantitative Health Science & Engineering, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Mohammed AbdulmageedDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Hend MohamedDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Sherif Abdelfattah IbrahimDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-9201-4519
Ranga P ThiruvenkataramaniDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Tarek MohamedDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-4789-5214
Masamitsu KanadaThe Institute for Quantitative Health Science & Engineering, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0001-9025-9582
Burra V MadhukarDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Myrna Gonzalez ArellanoDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Mohammed M SayedDepartment of Pediatrics and Neonatology, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
Heba M QubaisyDepartment of Pediatrics and Neonatology, Faculty of Medicine, South Valley University, Qena 83523, Egypt.
Said A OmarDivision of Neonatology, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-5152-5216
Michigan State University · USSparrow Hospital · USSouth Valley University · EGMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem cells (MSCs) have been used for ex vivo expansion of umbilical cord blood (UCB) hematopoietic stem cells (HSCs) to maintain their primitive characters and long-term reconstitution abilities during transplantation. Therapeutic effects of MSCs mainly rely on paracrine mechanisms, including secretion of exosomes (Exos). The objective of this study was to examine the effect of cord blood plasma (CBP)-derived Exos (CBP Exos) and Placental MSCs-derived Exos (MSCs Exos) on the expansion of UCB HSCs to increase their numbers and keep their primitive characteristics.

methodsCD34

resultsCBP Exos and MSCs Exos compared with the control group significantly increased the number of total nucleated cells (TNCs), invitro expansion of CD34

conclusionCBP- and placental-derived exosomes are associated with significant ex vivo expansion of UCB HSCs, while maintaining their primitive characters and may eliminate the need for transplantation of an additional unit of UCB.

Indexed as

ExosomesMesenchymal Stem CellsCell ProliferationFemaleFetal BloodHematopoietic Stem CellsHumansPlacentaPregnancyexosomesextracellular vesicles (EVs)hematopoietic stem cellsmesenchymal stem cellsplacentaumbilical cordumbilical cord blood transplantation

Identifiers

PMID36672185
PMCPMC9857343
OpenAlexW4313826367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.