Evidence map›Paper›PMID 36672184›Full record

ArticleCells2023

The Effects of Combined Exposure to Simulated Microgravity, Ionizing Radiation, and Cortisol on the

Wilhelmina E Radstake, Kiran Gautam, Silvana Miranda, Randy Vermeesen, Kevin Tabury, Emil Rehnberg, Jasmine Buset, Ann Janssen, Liselotte Leysen, Mieke Neefs and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Application of Microgravity Experiments in Plastic Surgery: A Literature Review.Plastic and reconstructive surgery. Global open · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors.International journal of molecular sciences · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Wilhelmina E RadstakeRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0002-1019-3139
Kiran GautamRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0003-4369-5036
Silvana MirandaRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Randy VermeesenRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0002-9850-8907
Kevin TaburyRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0002-8004-3718
Emil RehnbergRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0002-5318-5139
Jasmine BusetRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Ann JanssenRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Liselotte LeysenRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Mieke NeefsRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Mieke VerslegersRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Jürgen ClaesenMicrobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.
Marc-Jan van GoethemDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands.
Uli WeberGSI Helmholtzzentrum für Schwerionenforschung GmbH, Biophysics Division, 64291 Darmstadt, Germany.
Claudia FournierGSI Helmholtzzentrum für Schwerionenforschung GmbH, Biophysics Division, 64291 Darmstadt, Germany.
Alessio ParisiRadiation Protection Dosimetry and Calibration Expert Group, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0002-9323-8012
Sytze BrandenburgDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands.
Marco DuranteGSI Helmholtzzentrum für Schwerionenforschung GmbH, Biophysics Division, 64291 Darmstadt, Germany.ORCID 0000-0002-4615-553X
Bjorn BaseletRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0001-9840-2822
Sarah BaatoutRadiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), 2400 Mol, Belgium.ORCID 0000-0001-8110-751X
Belgian Nuclear Research Centre · BEGhent University · BEGSI Helmholtz Centre for Heavy Ion Research · DEUniversity Medical Center Groningen · NLUniversity of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human spaceflight is associated with several health-related issues as a result of long-term exposure to microgravity, ionizing radiation, and higher levels of psychological stress. Frequent reported skin problems in space include rashes, itches, and a delayed wound healing. Access to space is restricted by financial and logistical issues; as a consequence, experimental sample sizes are often small, which limits the generalization of the results. Earth-based simulation models can be used to investigate cellular responses as a result of exposure to certain spaceflight stressors. Here, we describe the development of an

Indexed as

WeightlessnessHumansHydrocortisoneRadiation, IonizingWeightlessness SimulationWound HealingHydrocortisonecarbon ionscortisolfibroblastin vitroionizing radiationiron ionsprotonssimulated microgravitywound healing

Identifiers

PMID36672184
PMCPMC9857207
OpenAlexW4313826585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.