Evidence map›Paper›PMID 36672146›Full record

ArticleCells2023

Aglianico Grape Seed Semi-Polar Extract Exerts Anticancer Effects by Modulating MDM2 Expression and Metabolic Pathways.

Rossana Cuciniello, Francesco Di Meo, Maria Sulli, Olivia Costantina Demurtas, Mirella Tanori, Mariateresa Mancuso, Clizia Villano, Riccardo Aversano, Domenico Carputo, Alfonso Baldi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cells · 2026
    Article
  2. miRNA-503 inhibition exerts anticancer effects and reduces tumor growth in mesothelioma.Journal of experimental & clinical cancer research : CR · 2025
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Rossana CucinielloInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino 111, 80131 Naples, Italy.
Francesco Di MeoInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino 111, 80131 Naples, Italy.
Maria SulliDivision of Biotechnology and Agroindustry, Biotechnology Laboratory, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-6875-2546
Olivia Costantina DemurtasDivision of Biotechnology and Agroindustry, Biotechnology Laboratory, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0003-3344-5754
Mirella TanoriDivision of Health Protection Technologies, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.
Mariateresa MancusoDivision of Health Protection Technologies, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-0912-9287
Clizia VillanoDepartment of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy.ORCID 0000-0001-9407-0146
Riccardo AversanoDepartment of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy.
Domenico CarputoDepartment of Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy.ORCID 0000-0003-1735-9338
Alfonso BaldiInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-8693-3842
Gianfranco DirettoDivision of Biotechnology and Agroindustry, Biotechnology Laboratory, ENEA, Casaccia Research Center, Via Anguillarese 301, 00123 Rome, Italy.ORCID 0000-0002-1441-0233
Stefania FilosaInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino 111, 80131 Naples, Italy.ORCID 0000-0003-2896-3362
Stefania CrispiInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino 111, 80131 Naples, Italy.
National Agency for New Technologies, Energy and Sustainable Economic Development · ITUniversity of Naples Federico II · ITInstitute of Biosciences and Bioresources · ITIstituto Neurologico Mediterraneo · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Grapevine (

Indexed as

Grape Seed ExtractMesotheliomaProanthocyanidinsVitisAnimalsHumansMetabolic Networks and PathwaysMiceProto-Oncogene Proteins c-mdm2SeedsGrape Seed ExtractMDM2 protein, humanProanthocyanidinsProto-Oncogene Proteins c-mdm2apoptosiscancer metabolismgene expressiongrape-seed extractMDM2natural moleculesproanthocyanidins

Identifiers

PMID36672146
PMCPMC9856309
OpenAlexW4313584166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.