Evidence map›Paper›PMID 36672139›Full record

ArticleCells2023

Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.

Arpita Deb, Brian D Tow, You Qing, Madelyn Walker, Emmanuel R Hodges, James A Stewart, Björn C Knollmann, Yi Zheng, Ying Wang, Bin Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Arpita DebDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Brian D TowDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
You QingBeijing Key Laboratory for Agricultural Application and New Technique, College of Plant Science and Technology, Bioinformatics Center, Beijing University of Agriculture, Beijing 102206, China.
Madelyn WalkerDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Emmanuel R HodgesSchool of Pharmacy, Division of BioMolecular Sciences, University of Mississippi, Oxford, MS 38677, USA.
James A StewartSchool of Pharmacy, Division of BioMolecular Sciences, University of Mississippi, Oxford, MS 38677, USA.ORCID 0000-0001-8920-8809
Björn C KnollmannDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Yi ZhengBeijing Key Laboratory for Agricultural Application and New Technique, College of Plant Science and Technology, Bioinformatics Center, Beijing University of Agriculture, Beijing 102206, China.
Ying WangDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.ORCID 0000-0002-9659-977X
Bin LiuDepartment of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Mississippi State University · USBeijing University of Agriculture · CNUniversity of Mississippi · USVanderbilt University · US

Funding

Exploring the role of mitochondria in dysregulated calcium handling in diseased heartsR15HL154073 · NHLBI · MISSISSIPPI STATE UNIVERSITY · PI LIU, BIN · 2021 to 2021
$423k
NHLBI NIH HHS R15 HL154073
6 · The paper itself

Abstract

The brief opening mode of the mitochondrial permeability transition pore (mPTP) serves as a calcium (Ca

Indexed as

Ryanodine Receptor Calcium Release ChannelTachycardia, VentricularAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2CalsequestrinMiceMice, KnockoutMitochondrial Permeability Transition PoreMyocytes, CardiacCalcium-Calmodulin-Dependent Protein Kinase Type 2CalsequestrinMitochondrial Permeability Transition PoreRyanodine Receptor Calcium Release Channelcalcium signalingCPVTEC-couplingmitochondria

Identifiers

PMID36672139
PMCPMC9856515
OpenAlexW4313585232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.