ArticleBrain sciences2023
Neurocognitive Endophenotypes for Eating Disorders: A Preliminary High-Risk Family Study.
Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- A Systematic Review to Explore a Neuropsychological Profile that Predates Anorexia Nervosa.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Pooled it
- Psychiatric Morbidity Is Overrepresented in Young Girls at High Risk of Developing Anorexia Nervosa.The International journal of eating disorders · 2026Article
- Identifying Distinct Latent Profiles of Executive Functioning Among Adolescents and Adults With Anorexia Nervosa and Adolescent Healthy Controls.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Neurocognitive impairments in eating disorders patients with and without comorbid food addiction.Journal of eating disorders · 2025Article
- Protective and risk factors for eating disorders: protocol for a prospective cohort study of children at familial high risk (BLOOM).BMJ open · 2025Article
- Neurobiology and Cognition in Girls at High-Risk of Eating Disorders: Exploring Imaging-Derived Trait Markers.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Neuropsychological profile in young girls at high risk of developing anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Cognitive remediation therapy for patients with eating disorders: a qualitative study.Journal of eating disorders · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
Eating disorders (EDs) are psychiatric disorders with a neurobiological basis. ED-specific neuropsychological and brain characteristics have been identified, but often in individuals in the acute phase or recovered from EDs, precluding an understanding of whether they are correlates and scars of EDs vs. predisposing factors. Although familial high-risk (FHR) studies are available across other disorders, this study design has not been used in EDs. We carried out the first FMH study in EDs, investigating healthy offspring of women with EDs and controls. We preliminarily aimed to investigate ED-related neurocognitive and brain markers that could point to predisposing factors for ED. Sixteen girls at FHR for EDs and twenty control girls (age range: 8−15), completed neuropsychological tests assessing executive functions. Girls also underwent a resting-state fMRI scan to quantify functional connectivity (FC) within resting-state networks. Girls at FHR for EDs performed worse on a cognitive flexibility task compared with controls (F = 5.53, p = 0.02). Moreover, they showed different FC compared with controls in several resting-state networks (p < 0.05 FDR-corrected). Differences identified in cognitive flexibility and in FC are in line with those identified in individuals with EDs, strongly pointing to a role as potential endophenotypes of EDs.
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Registered trials
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