Evidence map›Paper›PMID 36672074›Full record

ReviewBrain sciences2023

Balance Rehabilitation through Robot-Assisted Gait Training in Post-Stroke Patients: A Systematic Review and Meta-Analysis.

Alberto Loro, Margherita Beatrice Borg, Marco Battaglia, Angelo Paolo Amico, Roberto Antenucci, Paolo Benanti, Michele Bertoni, Luciano Bissolotti, Paolo Boldrini, Donatella Bonaiuti and 36 more

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Combined exercise training to improve gait in older stroke patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  4. Effectiveness of combined robotics and virtual reality on lower limb functional ability in stroke survivors: A systematic review of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  20. Enhanced Rehabilitation Outcomes of Robotic-Assisted Gait Training with EksoNR Lower Extremity Exoskeleton in 19 Stroke Patients.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 1 country.

Alberto LoroDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0002-8116-4802
Margherita Beatrice BorgDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0002-0831-4843
Marco BattagliaDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0003-1357-1374
Angelo Paolo AmicoPhysical Medicine and Rehabilitation Unit, Polyclinic of Bari, 70124 Bari, Italy.
Roberto AntenucciRehabilitation Unit, Castel San Giovanni Hospital, 29015 Piacenza, Italy.
Paolo BenantiTheology Department, Pontifical Gregorian University, 00187 Rome, Italy.ORCID 0000-0001-9482-0090
Michele BertoniPhysical Medicine and Rehabilitation, ASST Sette Laghi, 21100 Varese, Italy.
Luciano BissolottiCasa di Cura Domus Salutis, Fondazione Teresa Camplani, 25100 Brescia, Italy.
Paolo BoldriniRobotic Rehabilitation Section, Italian Society of Physical and Rehabilitative Medicine (SIMFER), 00187 Rome, Italy.
Donatella BonaiutiRobotic Rehabilitation Section, Italian Society of Physical and Rehabilitative Medicine (SIMFER), 00187 Rome, Italy.
Thomas BowmanNeurorehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.
Marianna CapecciExperimental and Clinic Medicine Department, Università Politecnica delle Marche (UNIVPM), 60126 Ancona, Italy.
Enrico CastelliNeurorehabilitation Unit, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Loredana CavalliPhysical Medicine and Rehabilitation Unit, Centro Giusti, 50125 Florence, Italy.ORCID 0000-0003-4075-933X
Nicoletta CinoneUnit of Spasticity and Movement Disorders, Division of Physical Medicine and Rehabilitation, University Hospital of Foggia, 71100 Foggia, Italy.ORCID 0000-0002-5389-3290
Lucia CosenzaRehabilitation Unit, Department of Rehabilitation, "Santi Antonio e Biagio e Cesare Arrigo" National Hospital, 15122 Alessandria, Italy.
Rita Di CensoUnit of Neurorehabilitation, Department of Neuroscience, Biomedicine, and Movement Sciences, University Hospital of Verona, University of Verona, 37126 Verona, Italy.
Giuseppina Di StefanoRobotic Rehabilitation Section, Italian Society of Physical and Rehabilitative Medicine (SIMFER), 00187 Rome, Italy.
Francesco DraicchioDipartimento Medicina, Epidemiologia, Igiene del Lavoro e Ambientale, Istituto Nazionale Assicurazione Infortuni sul Lavoro (INAIL), 00192 Rome, Italy.
Vincenzo FalabellaItalian Federation of Persons with Spinal Cord Injuries (FISH), 00197 Rome, Italy.
Mirko FilippettiUnit of Neurorehabilitation, Department of Neuroscience, Biomedicine, and Movement Sciences, University Hospital of Verona, University of Verona, 37126 Verona, Italy.ORCID 0000-0001-5930-5974
Silvia GaleriNeurorehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.
Francesca GimiglianoDepartment of Physical and Mental Health and Prevention Medicine, Luigi Vanvitelli University of Campania, 81100 Naples, Italy.
Mauro GrigioniDepartment of New Technologies in Public Healthcare, Italian National Institute of Health (ISS), 00161 Rome, Italy.ORCID 0000-0002-8231-8156
Marco InvernizziTranslational Medicine, Dipartimento Attività Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, 15122 Alessandria, Italy.ORCID 0000-0001-5141-0681
Johanna JonsdottirNeurorehabilitation Department, IRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.ORCID 0000-0002-8287-4881
Carmelo LentinoRehabilitation Unit, Santa Corona Hospital, 17027 Pietra Ligure, Italy.
Perla MassaiTuscany Rehabilitation Clinic, 52025 Montevarchi, Italy.
Stefano MazzoleniDepartment of Electrical Engineering and Information Technology, Polytechnic University of Bari, 70126 Bari, Italy.ORCID 0000-0002-9528-3239
Stefano MazzonAzienda Unità Locale Socio Sanitaria Euganea (AULSS 6), 35100 Padua, Italy.
Franco MolteniRehabilitation Department, Valduce Villa Beretta Hospital, 23845 Costa Masnaga, Italy.
Sandra MorelliDepartment of New Technologies in Public Healthcare, Italian National Institute of Health (ISS), 00161 Rome, Italy.
Giovanni MoroneNeurorehabilitation Unit, Santa Lucia Foundation IRCCS, 00179 Rome, Italy.
Antonio NardonePediatric, Diagnostical and Clinical-Surgical Sciences Department, University of Pavia, 27100 Pavia, Italy.
Daniele PanzeriPediatric Rehabilitation Unit, IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy.
Maurizio PetrarcaNeurorehabilitation Unit, Bambino Gesù Children's Hospital, 00165 Rome, Italy.
Federico PosteraroRehabilitation Unit, Versilia Hospital, 55041 Camaiore, Italy.
Andrea SantamatoUnit of Spasticity and Movement Disorders, Division of Physical Medicine and Rehabilitation, University Hospital of Foggia, 71100 Foggia, Italy.ORCID 0000-0002-1452-8485
Lorenza ScottiDepartment of Translational Medicine, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.
Michele SenatoreItalian Association of Occupational Therapists (AITO), 00136 Rome, Italy.
Stefania SpinaUnit of Spasticity and Movement Disorders, Division of Physical Medicine and Rehabilitation, University Hospital of Foggia, 71100 Foggia, Italy.ORCID 0000-0002-7220-4016
Elisa TaglioneRehabilitation Unit, Istituto Nazionale Assicurazione Infortuni sul Lavoro (INAIL), 56048 Volterra, Italy.
Giuseppe TurchettiInstitute of Management, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.ORCID 0000-0002-1877-5459
Valentina VaraltaUnit of Neurorehabilitation, Department of Neuroscience, Biomedicine, and Movement Sciences, University Hospital of Verona, University of Verona, 37126 Verona, Italy.
Alessandro PicelliUnit of Neurorehabilitation, Department of Neuroscience, Biomedicine, and Movement Sciences, University Hospital of Verona, University of Verona, 37126 Verona, Italy.ORCID 0000-0002-3558-8276
Alessio BaricichDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0001-8440-6283
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Verona · ITDon Carlo Gnocchi Foundation · ITUniversity of Foggia · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITBambino Gesù Children's Hospital · ITIstituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro · ITScuola Superiore Sant'Anna · ITAziende Socio Sanitarie Territoriale dei Sette LaghiFondazione Santa Lucia · ITIRCCS Eugenio Medea · ITItalian Association for Cancer Research · ITMarche Polytechnic University · ITOspedale Santa Corona · ITOspedale Valduce · ITOspedale Versilia · ITPontifical Gregorian University · ITUniversity of Bari Aldo Moro · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBalance impairment is a common disability in post-stroke survivors, leading to reduced mobility and increased fall risk. Robotic gait training (RAGT) is largely used, along with traditional training. There is, however, no strong evidence about RAGT superiority, especially on balance. This study aims to determine RAGT efficacy on balance of post-stroke survivors.

methodsPubMed, Cochrane Library, and PeDRO databases were investigated. Randomized clinical trials evaluating RAGT efficacy on post-stroke survivor balance with Berg Balance Scale (BBS) or Timed Up and Go test (TUG) were searched. Meta-regression analyses were performed, considering weekly sessions, single-session duration, and robotic device used.

resultsA total of 18 trials have been included. BBS pre-post treatment mean difference is higher in RAGT-treated patients, with a pMD of 2.17 (95% CI 0.79; 3.55). TUG pre-post mean difference is in favor of RAGT, but not statistically, with a pMD of -0.62 (95%CI - 3.66; 2.43). Meta-regression analyses showed no relevant association, except for TUG and treatment duration (β = -1.019, 95% CI - 1.827; -0.210,

conclusionsRAGT efficacy is equal to traditional therapy, while the combination of the two seems to lead to better outcomes than each individually performed. Robot-assisted balance training should be the focus of experimentation in the following years, given the great results in the first available trials. Given the massive heterogeneity of included patients, trials with more strict inclusion criteria (especially time from stroke) must be performed to finally define if and when RAGT is superior to traditional therapy.

Indexed as

balancegaitrehabilitationroboticsstroke

Identifiers

PMID36672074
PMCPMC9856764
OpenAlexW4313585674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.