Evidence map›Paper›PMID 36671918›Full record

ReviewBiosensors2023

A Review on Microfluidics-Based Impedance Biosensors.

Yu-Shih Chen, Chun-Hao Huang, Ping-Ching Pai, Jungmok Seo, Kin Fong Lei

Abstract readReview
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  11. Advances in Microengineered Platforms for Skin Research.JID innovations : skin science from molecules to population health · 2025
    Review
  12. Review
  13. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yu-Shih ChenDepartment of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-3238-5756
Chun-Hao HuangDepartment of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.
Ping-Ching PaiDepartment of Radiation Oncology, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Jungmok SeoDepartment of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-8898-044X
Kin Fong LeiDepartment of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0002-5356-2221

Funding

National Research Foundation of Korea 2022R1A2C4001652National Science and Technology Council, Taiwan MOST111-2221-E-182-006-MY3
6 · The paper itself

Abstract

Electrical impedance biosensors are powerful and continuously being developed for various biological sensing applications. In this line, the sensitivity of impedance biosensors embedded with microfluidic technologies, such as sheath flow focusing, dielectrophoretic focusing, and interdigitated electrode arrays, can still be greatly improved. In particular, reagent consumption reduction and analysis time-shortening features can highly increase the analytical capabilities of such biosensors. Moreover, the reliability and efficiency of analyses are benefited by microfluidics-enabled automation. Through the use of mature microfluidic technology, complicated biological processes can be shrunk and integrated into a single microfluidic system (e.g., lab-on-a-chip or micro-total analysis systems). By incorporating electrical impedance biosensors, hand-held and bench-top microfluidic systems can be easily developed and operated by personnel without professional training. Furthermore, the impedance spectrum provides broad information regarding cell size, membrane capacitance, cytoplasmic conductivity, and cytoplasmic permittivity without the need for fluorescent labeling, magnetic modifications, or other cellular treatments. In this review article, a comprehensive summary of microfluidics-based impedance biosensors is presented. The structure of this article is based on the different substrate material categorizations. Moreover, the development trend of microfluidics-based impedance biosensors is discussed, along with difficulties and challenges that may be encountered in the future.

Indexed as

Biosensing TechniquesMicrofluidic Analytical TechniquesElectric ImpedanceLab-On-A-Chip DevicesMicrofluidicsReproducibility of Resultselectrical impedance flow cytometerelectrochemical impedance spectroscopyimpedance biosensormicrofluidic

Identifiers

PMID36671918
PMCPMC9855525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.