Evidence map›Paper›PMID 36671851›Full record

ReviewBiosensors2022

Fluorescent Sensing of Glutathione and Related Bio-Applications.

Xiaohuan Sun, Fei Guo, Qianyun Ye, Jinfeng Zhou, Jie Han, Rong Guo

Abstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaohuan SunSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.ORCID 0000-0001-5655-131X
Fei GuoSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Qianyun YeSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Jinfeng ZhouSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Jie HanSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Rong GuoSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.

Funding

Chinese Postdoctoral Science Foundation 2021M692714National Natural Science Foundation of China 21922202National Natural Science Foundation of China 22002138National Natural Science Foundation of China 22272146
6 · The paper itself

Abstract

Glutathione (GSH), as the most abundant low-molecular-weight biological thiol, plays significant roles in vivo. Abnormal GSH levels have been demonstrated to be related to the dysfunction of specific physiological activities and certain kinds of diseases. Therefore, the sensing of GSH is emerging as a critical issue. Cancer, with typical high morbidity and mortality, remains one of the most serious diseases to threaten public health. As it is clear that much more concentrated GSH is present at tumor sites than at normal sites, the in vivo sensing of GSH offers an option for the early diagnosis of cancer. Moreover, by monitoring the amounts of GSH in specific microenvironments, effective diagnosis of ROS levels, neurological diseases, or even stroke has been developed as well. In this review, we focus on the fluorescent methodologies for GSH detection, since they can be conveniently applied in living systems. First, the fluorescent sensing methods are introduced. Then, the principles for fluorescent sensing of GSH are discussed. In addition, the GSH-sensing-related biological applications are reviewed. Finally, the future opportunities in in the areas of fluorescent GSH sensing-in particular, fluorescent GSH-sensing-prompted disease diagnosis-are addressed.

Indexed as

Fluorescent DyesNeoplasmsGlutathioneHumansSulfhydryl CompoundsTumor MicroenvironmentFluorescent DyesGlutathioneSulfhydryl Compoundsbio-applicationscancer diagnosisfluorescent sensingglutathione

Identifiers

PMID36671851
PMCPMC9855688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.