Evidence map›Paper›PMID 36671604›Full record

ArticleBioengineering (Basel, Switzerland)2022

The Effect of Tissue Stromal Vascular Fraction as Compared to Cellular Stromal Vascular Fraction to Treat Anal Sphincter Incontinence.

Wenbin Chen, Zijian He, Shuyu Li, Zixin Wu, Jin Tan, Weifeng Yang, Guanwei Li, Xiaoling Pan, Yuying Liu, Feng-Juan Lyu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wenbin ChenDepartment of Colorectal and Anal Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Zijian HeDepartment of Colorectal and Anal Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Shuyu LiSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510641, China.
Zixin WuDepartment of Colorectal and Anal Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Jin TanThe Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Weifeng YangDepartment of Colorectal and Anal Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Guanwei LiDepartment of Colorectal and Anal Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Xiaoling PanThe Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Yuying LiuThe Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Feng-Juan LyuThe Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
Wanglin LiDepartment of Colorectal and Anal Surgery, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 510641, China.
South China University of Technology · CN

Funding

Clinical Specialty Technology Program of Guangzhou, China 2019TS52Guangdong Basic and Applied Basic Research Foundation 2021B1515420004Guangdong Digestive System Disease Clinical Research Center Program 2020B1111170004Guangzhou High-level Key Clinical Specialty Construction Project No.9Guangzhou science and Technology Program SYPTKTB2019058Natural Science Foundation of Guangdong Provinc 2020A1515011031Science and Technology Projects in Guangzhou 202201020363
6 · The paper itself

Abstract

backgroundThe long-term prognosis of current treatments for anal sphincter incontinence (ASI) is poor. Here, we explored the efficacy of tissue adipose stromal vascular fraction SVF (tSVF) on ASI and compared it to that of cellular SVF (cSVF). We then investigated possible mechanisms.

methodsRat cSVF and tSVF were isolated and labeled with DIL. One day after modeling, three groups received phosphate-buffered saline (PBS), cSVF, tSVF, respectively. The control group received nil modeling nor any treatments. The effect was assessed by function test for anal pressure and electromyography, and staining for fiber content, proliferation and differentiation at day 5 and day 10.

resultscSVF injection resulted in faster healing than tSVF. The cSVF group showed significant improvement on anal pressure on day 10. For the electromyography test, cSVF showed significant improvement for the frequencies on day 10, and for the peak values on both time points, while tSVF showed significant improvement for the peak values on day 10. The two SVF both alleviated fibrosis. Immunofluorescence tracing identified differentiation of some injected cells towards myosatellite cells and smooth muscle cells in both SVF groups. For all the tests, the tSVF group tends to have similar or lower effects than the cSVF group with no significant difference.

conclusioncSVF and tSVF are both safe and effective in treating ASI, while the effect of cSVF is slighter higher than tSVF.

Indexed as

anal sphincter incontinencecVSFtSVF

Identifiers

PMID36671604
PMCPMC9854502
OpenAlexW4313261040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.