Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy.

Muhammad Hassan, David R Grattan, Beulah Leitch

Open access · goldAbstract read

In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention.International journal of molecular sciences · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Muhammad HassanDepartment of Anatomy, School of Biomedical Sciences, Brain Health Research Centre, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.

David R GrattanDepartment of Anatomy, School of Biomedical Sciences, Brain Health Research Centre, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.ORCID 0000-0001-5606-2559

Beulah LeitchDepartment of Anatomy, School of Biomedical Sciences, Brain Health Research Centre, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand.

University of Otago · NZ

Funding

University of Otago

6 · The paper itself

Abstract

Childhood absence epilepsy seizures arise in the cortico-thalamocortical network due to multiple cellular and molecular mechanisms, which are still under investigation. Understanding the precise mechanisms is imperative given that treatment fails in ~30% of patients while adverse neurological sequelae remain common. Impaired GABAergic neurotransmission is commonly reported in research models investigating these mechanisms. Recently, we reported a region-specific reduction in the whole-tissue and synaptic GABA

Indexed as

Epilepsy, AbsenceAnimalsgamma-Aminobutyric AcidMiceReceptors, GABA-ASeizuresSomatosensory Cortexgamma-Aminobutyric AcidReceptors, GABA-Aabsence epilepsyabsence seizuresbiochemical fractionationcortico-thalamocortical networkGABAA receptorpostnatal developmentprimary somatosensory cortexstargazer mouse

Identifiers

PMID36671571

DOI10.3390/biom13010186

PMCPMC9856073

OpenAlexW4317036522

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.