Evidence map›Paper›PMID 36671535›Full record

ArticleBiomolecules2023

Antimicrobial Spectrum of Activity and Mechanism of Action of Linear Alpha-Helical Peptides Inspired by Shrimp Anti-Lipopolysaccharide Factors.

Gabriel Machado Matos, Beatriz Garcia-Teodoro, Camila Pimentel Martins, Paulina Schmitt, Fanny Guzmán, Ana Claudia Oliveira de Freitas, Patricia Hermes Stoco, Fabienne Antunes Ferreira, Marciel João Stadnik, Diogo Robl and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
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  4. Article
  5. Design and Synthesis of Novel Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Gabriel Machado MatosLaboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.ORCID 0000-0003-3744-2673
Beatriz Garcia-TeodoroLaboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.ORCID 0000-0003-0556-1985
Camila Pimentel MartinsLaboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
Paulina SchmittLaboratorio de Genética e Inmunología Molecular, Instituto de Biología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, Chile.
Fanny GuzmánNúcleo Biotecnología Curauma, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, Chile.ORCID 0000-0002-7829-0568
Ana Claudia Oliveira de FreitasLaboratory of Protozoology, Department of Microbiology, Parasitology and Immunology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
Patricia Hermes StocoLaboratory of Protozoology, Department of Microbiology, Parasitology and Immunology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
Fabienne Antunes FerreiraLaboratory of Molecular Genetics of Bacteria, Department of Microbiology, Parasitology and Immunology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.ORCID 0000-0002-6444-6007
Marciel João StadnikLaboratory of Plant Pathology, Department of Plant Sciences, Federal University of Santa Catarina, Florianópolis 88034-001, Brazil.ORCID 0000-0002-4108-7427
Diogo RoblLaboratory of Microorganisms and Biotechnological Processes, Department of Microbiology, Parasitology and Immunology, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.
Luciane Maria PerazzoloLaboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.ORCID 0000-0002-5539-4911
Rafael Diego RosaLaboratory of Immunology Applied to Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, Florianópolis 88040-900, Brazil.ORCID 0000-0002-4076-3163
Universidade Federal de Santa Catarina · BRPontificia Universidad Católica de Valparaíso · CL

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 1974/2014FONDECYT 1200129National Council for Scientific and Technological Development 406530/2016-5, 304352/2019-5 and 312047/2021-5
6 · The paper itself

Abstract

Shrimp antilipopolysaccharide factors (ALFs) form a multifunctional and diverse family of antimicrobial host defense peptides (AMPs) composed of seven members (groups A to G), which differ in terms of their primary structure and biochemical properties. They are amphipathic peptides with two conserved cysteine residues stabilizing a central β-hairpin that is understood to be the core region for their biological activities. In this study, we synthetized three linear (cysteine-free) peptides based on the amino acid sequence of the central β-hairpin of the newly identified shrimp (

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesGram-Negative BacteriaGram-Positive BacteriaHumansLipopolysaccharidesMicrobial Sensitivity TestsProtein Conformation, alpha-HelicalAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesLipopolysaccharidesantibacterialantifungalantimicrobial peptide (AMP)antiparasitic activitycrustaceancytotoxicityhost defense peptide (HDP)membrane-disruptingmethicillin-resistant Staphylococcus aureus (MRSA)synergy

Identifiers

PMID36671535
PMCPMC9856130
OpenAlexW4315646782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.