Evidence map›Paper›PMID 36671517›Full record

ArticleBiomolecules2023

Genetic Predisposition to Neurological Complications in Patients with COVID-19.

Nikhil Shri Sahajpal, Alex R Hastie, Maximilian Schieck, Ashis K Mondal, Marc Felde, Caspar I van der Made, Janet S Chou, Adrienne G Randolph, Thomas Illig, Michael C Zody and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Nikhil Shri SahajpalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Alex R HastieBionano Genomics, Inc., San Diego, CA 92121, USA.
Maximilian SchieckHannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-5878-0546
Ashis K MondalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3826-9489
Marc FeldeDepartment of Human Genetics, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-6132-5026
Caspar I van der MadeDepartment of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands.ORCID 0000-0003-0763-4017
Janet S ChouDivision of Immunology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Adrienne G RandolphDepartment of Anesthesiology, Critical Care, and Pain Medicine, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Thomas IlligHannover Unified Biobank, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0003-4284-5389
Michael C ZodyNew York Genome Center, New York, NY 10013, USA.
Catherine A BrownsteinDivision of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Alan H BeggsDivision of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8818-0568
Alexander HoischenDepartment of Human Genetics, Radboud University Medical Center for Infectious Diseases (RCI), 6525 Nijmegen, The Netherlands.
Alka ChaubeyBionano Genomics, Inc., San Diego, CA 92121, USA.ORCID 0000-0002-0914-9237
Ravindra KolheDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8283-2403
COVID19hostgenomesv Consortium
Boston Children's Hospital · USAugusta University · USMedizinische Hochschule Hannover · DEBioNano Genomics (United States) · USRadboud University Nijmegen · NLNew York Genome Center · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

Indexed as

COVID-19Nervous System DiseasesGenetic Predisposition to DiseaseGenotypeHumansCOVID-19genetic predispositionneurological complicationsoptical genome mappingrare SVs

Identifiers

PMID36671517
PMCPMC9855758
OpenAlexW4313827563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.