Evidence map›Paper›PMID 36671465›Full record

ArticleBiomolecules2022

The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain.

Nuzhat Parveen, Wei-Jung Chiu, Li-Ching Shen, Ruey-Hwang Chou, Chung-Ming Sun, Chin Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. TetronicPharmaceutics · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nuzhat ParveenChemistry Department, National Tsing Hua University, Hsinchu 300, Taiwan.
Wei-Jung ChiuDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Li-Ching ShenDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0003-1065-6575
Ruey-Hwang ChouGraduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-2297-2180
Chung-Ming SunDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Chin YuChemistry Department, National Tsing Hua University, Hsinchu 300, Taiwan.
National Yang Ming Chiao Tung University · TWNational Tsing Hua University · TWAsia University · TW

Funding

China Medical University and HsinChu Hospital CMUHCH-CMU-112-003China Medical University and HsinChu Hospital: CMUHCH-CMU-112-003 China Medical University Hospital DMR-112-173Ministry of science and technology MOST107B3079I5Ministry of Science and Technology MOST107-2113-M-009 -018 -MY3Ministry of Science and Technology MOST 110-2320-B-039-031
6 · The paper itself

Abstract

The S100A1 protein in humans is a calcium-binding protein. Upon Ca

Indexed as

NeoplasmsPentamidineAntigens, NeoplasmCalciumHumansMagnetic Resonance SpectroscopyMitogen-Activated Protein KinasesProtein BindingS100 ProteinsSignal TransductionAntigens, NeoplasmCalciumMitogen-Activated Protein KinasesMOK protein, humanPentamidineS100A1 proteinS100 Proteinscell proliferationcytotoxicitydockingprotein–ligand interactionsmall compound WLC-4059

Identifiers

PMID36671465
PMCPMC9856166
OpenAlexW4313472964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.