ReviewBiomolecules2022
The Important Role of Zinc in Neurological Diseases.
Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Impact of maternal micronutrient supplementation on pregnancy outcomes in developing countries: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Actual Data on Essential Trace Elements in Parkinson's Disease.Nutrients · 2025Pooled it
- Food-Derived Zinc-Chelating Peptides: Coordination Chemistry, Intestinal Transport, and Nutritional Functionality.Nutrients · 2026Review
- Metal Binding to Tau Protein: Physiological and Pathological Relevance.Biochemistry · 2026Review
- Zinc dyshomeostasis, mitochondrial dysfunction, and their pathological cycle in ischemic stroke pathophysiology: Mechanisms and potential therapeutic targets.Redox biology · 2026Review
- Design and Development of Solvent-Sensitive Zn(II)/Al(III) Responsive Chemosensor: Extension to the Real-World Application.ChemPlusChem · 2026Article
- Atomic Layer Deposition Processes: Versatile Platforms for Engineering ZnO-Chitosan Biointerfaces.Advanced healthcare materials · 2026Article
- Plasma Copper and Zinc Levels in Ataxia-Telangiectasia.International journal of molecular sciences · 2026Article
- A furano-RSC advances · 2026Article
- Impact of prenatal exposure to airborne particulate matter on local functional connections in the cerebral cortex of neonates.NeuroImage · 2026Article
- Biomimetic bone-like regeneration potentiality and strength development of Mg-Zn-Ca alloys for maxillofacial application.BMC oral health · 2026Article
- The therapeutic potential of zinc-nanoparticles against the cerebellar neurotoxicity induced by bacterial lipopolysaccharides in female rats and their pups.Scientific reports · 2026Article
- Preparation, Characteristics, Antioxidant and Anti-Inflammatory Activity of SeNPs and ZnO-enriched Limosilactobacillus reuteri LR1.Probiotics and antimicrobial proteins · 2026Article
- Review
- Association Between Mineral Intake and Cognitive Performance in Spanish Adults with Overweight and Obesity: A Cross-Sectional Study.Nutrients · 2026Article
- An Ultraresponsive Green Biosensor for Robust in Vivo Imaging of Synaptic Zinc Dynamics.ACS sensors · 2026Article
- Alcohol Use Disorder Affects Brain Metals.bioRxiv : the preprint server for biology · 2026Article
- Zinc in Soil-Plant-Human Systems: A Synthesis of Its Fate, Essential Roles, and Health Implications.Scientifica · 2026Review
- Development and translation of biodegradable metal stents: from heart to brain.Regenerative biomaterials · 2026Review
- Case Report: Identification of aFrontiers in genetics · 2026Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Zinc is one of the most abundant metal ions in the central nervous system (CNS), where it plays a crucial role in both physiological and pathological brain functions. Zinc promotes antioxidant effects, neurogenesis, and immune system responses. From neonatal brain development to the preservation and control of adult brain function, zinc is a vital homeostatic component of the CNS. Molecularly, zinc regulates gene expression with transcription factors and activates dozens of enzymes involved in neuronal metabolism. During development and in adulthood, zinc acts as a regulator of synaptic activity and neuronal plasticity at the cellular level. There are several neurological diseases that may be affected by changes in zinc status, and these include stroke, neurodegenerative diseases, traumatic brain injuries, and depression. Accordingly, zinc deficiency may result in declines in cognition and learning and an increase in oxidative stress, while zinc accumulation may lead to neurotoxicity and neuronal cell death. In this review, we explore the mechanisms of brain zinc balance, the role of zinc in neurological diseases, and strategies affecting zinc for the prevention and treatment of these diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.