Evidence map›Paper›PMID 36671391›Full record

ArticleBiomolecules2022

Metatranscriptomic Analysis Reveals Disordered Alterations in Oropharyngeal Microbiome during the Infection and Clearance Processes of SARS-CoV-2: A Warning for Secondary Infections.

Yongzhao Zhou, Sifen Lu, Xiaozhen Wei, Ya Hu, Honghao Li, Jing Wang, Yifei Lin, Mengjiao Li, Minjin Wang, Jinmin Ma and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. METTL3-mediated mMolecular biology reports · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Yongzhao ZhouDepartment of Integrated Care Management Center, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Sifen LuPrecision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaozhen WeiDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Ya HuCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-6652-5817
Honghao LiDepartment of Hospital Management, West China Hospital, Sichuan University, Chengdu 610041, China.
Jing WangPrecision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Yifei LinPrecision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Mengjiao LiDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Minjin WangDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Jinmin MaBGI-Shenzhen & BGI-PathoGenesis Pharmaceutical Technology, Shenzhen 518083, China.
Zhongyi ZhuBGI-Shenzhen & BGI-PathoGenesis Pharmaceutical Technology, Shenzhen 518083, China.
Shengying YangDepartment of Computer & Software, Jincheng College of Chengdu, Chengdu 611700, China.
Binwu YingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Wengeng ZhangPrecision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-1000-4692
Bojiang ChenDepartment of Integrated Care Management Center, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Weimin LiDepartment of Integrated Care Management Center, Frontier Science Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CNBGI Group (China) · CNChengdu Medical College · CN

Funding

K&D Program of the Sichuan Science and Technology Department, China 2020YFS0573Sichuan Province Science and Technology Support Program for Diagnostic and Treatment of COVID-19 2020YFS0001Sichuan Province Science and Technology Support Program for Diagnostic and Treatment of COVID-19 2020YFS0002Sichuan Province Science and Technology Support Program for Diagnostic and Treatment of COVID-19 2020YFS0572
6 · The paper itself

Abstract

This study was conducted to investigate oropharyngeal microbiota alterations during the progression of coronavirus disease 2019 (COVID-19) by analyzing these alterations during the infection and clearance processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The diagnosis of COVID-19 was confirmed by using positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-qPCR). The alterations in abundance, diversity, and potential function of the oropharyngeal microbiome were identified using metatranscriptomic sequencing analyses of oropharyngeal swab specimens from 47 patients with COVID-19 (within a week after diagnosis and within two months after recovery from COVID-19) and 40 healthy individuals. As a result, in the infection process of SARS-CoV-2, compared to the healthy individuals, the relative abundances of

Indexed as

CoinfectionCOVID-19Epstein-Barr Virus InfectionsMicrobiotaBacteriaHerpesvirus 4, HumanHumansSARS-CoV-2infection and clearance processesmetatranscriptomic sequencingoropharyngeal microbiomeSARS-CoV-2secondary infections

Identifiers

PMID36671391
PMCPMC9856197
OpenAlexW4312070696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.