Evidence map›Paper›PMID 36671288›Full record

ArticleAntibiotics (Basel, Switzerland)2023

Effect of Tocilizumab on Mortality in Patients with SARS-CoV-2 Pneumonia Caused by Delta or Omicron Variants: A Propensity-Matched Analysis in Nimes University Hospital, France.

Paul Laffont-Lozes, Didier Laureillard, Paul Loubet, Robin Stephan, Myriam Chiaruzzi, Edouard Clemmer, Aurelie Martin, Claire Roger, Laurent Muller, Pierre-Géraud Claret and 5 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paul Laffont-LozesDepartment of Pharmacy, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Didier LaureillardInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.ORCID 0000-0002-0104-9047
Paul LoubetInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.ORCID 0000-0002-1218-9432
Robin StephanDepartment of Microbiology and Hospital Hygiene, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Myriam ChiaruzziInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Edouard ClemmerInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Aurelie MartinInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Claire RogerAnesthesiology and Critical Care Medicine Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.ORCID 0000-0002-6055-0034
Laurent MullerAnesthesiology and Critical Care Medicine Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Pierre-Géraud ClaretEmergency Medicine Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Radjiv GoulabchandDepartment of Internal Medicine, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.ORCID 0000-0002-7328-4097
Clarisse RouxDepartment of Pharmacy, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.
Jean-Philippe LavigneDepartment of Microbiology and Hospital Hygiene, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.ORCID 0000-0002-9484-0304
Albert SottoInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.ORCID 0000-0002-6463-9386
Romaric LarcherInfectious and Tropical Diseases Department, Nimes University Hospital, Place du Professeur Robert Debre, 30000 Nimes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to assess the factors associated with mortality in patients treated with tocilizumab for a SARS-CoV-2 pneumonia due to the delta or omicron variants of concern (VOC) and detect an effect of tocilizumab on mortality. We conducted a prospective cohort study in a tertiary hospital from 1 August 2021 to 31 March 2022 including patients with severe COVID-19, treated with tocilizumab. Factors associated with mortality were assessed in a Cox model; then, the 60-day mortality rates of COVID-19 patients treated with standard of care (SoC) +/- tocilizumab were compared after 1:1 propensity score matching. The mortality rate was 22% (N = 26/118) and was similar between delta and omicron cases (

Indexed as

COVID-19early administrationinterleukin-6 receptor antagonistmortality ratesvariant of concern

Identifiers

PMID36671288
PMCPMC9854884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.